Renal injury in relation to obesity and the additive effect of hypertension in female and male obese and lean ZSF1 rats

Chronic kidney disease co-exists with heart failure with preserved ejection fraction (HFpEF), which is characterized by obesity, hypertension, and diabetes mellitus type 2. HFpEF is found predominantly in women in whom obesity and hypertension are particularly prevalent. Obese ZSF1 rats, a model of HFpEF, exhibit many of these comorbidities and disturbed cardiac function. However, little […]

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice

Heart failure has reached epidemic proportions in a progressively ageing population. The molecular mechanisms underlying heart failure remain elusive, but evidence indicates that DNA damage is enhanced in failing hearts. Here, we tested the hypothesis that endogenous DNA repair in cardiomyocytes is critical for maintaining normal cardiac function, so that perturbed repair of spontaneous DNA […]

Review: prognostic models for cardiovascular disease in patients with chronic kidney disease

Patients with chronic kidney disease (CKD) have a high risk of cardiovascular disease (CVD), which we want to ideally estimate using a prediction model, combining clinical and laboratory characteristics. In this review we aim to give an overview of CVD prognostic studies available, and their methodological quality, specifically for patients with CKD. A large quantity […]