Renal injury in relation to obesity and the additive effect of hypertension in female and male obese and lean ZSF1 rats
Chronic kidney disease co-exists with heart failure with preserved ejection fraction (HFpEF), which is characterized by obesity, hypertension, and diabetes mellitus type 2. HFpEF is found predominantly in women in whom obesity and hypertension are particularly prevalent. Obese ZSF1 rats, a model of HFpEF, exhibit many of these comorbidities and disturbed cardiac function. However, little […]
Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities.
Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic inflammation, increased oxidative stress and produced coronary endothelial dysfunction, altering control of coronary microvascular tone via loss of NO bioavailability, which was associated with […]
Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo-controlled, crossover trial
Heart failure with preserved ejection fraction (HFpEF) is a major healthcare burden with limited treatment options. Geranylgeranylacetone (GGA) has been shown to improve myocardial compliance and endothelial function in preclinical models. Given the mechanistic profile of GGA and established safety as an over-the-counter drug in Asia, we performed a phase 2 clinical trial in patients […]