Chronic kidney disease co-exists with heart failure with preserved ejection fraction (HFpEF), which is characterized by obesity, hypertension, and diabetes mellitus type 2. HFpEF is found predominantly in women in whom obesity and hypertension are particularly prevalent. Obese ZSF1 rats, a model of HFpEF, exhibit many of these comorbidities and disturbed cardiac function. However, little is known on how these comorbidities affect renal disease in ZSF1 rats. Therefore, we characterized renal phenotype in female and male, lean and obese, ZSF1 rats and investigated additional effects of worsened hypertension on disease severity. We showed that obese and mildly hypertensive female ZSF1 rats simultaneously develop renal disease with diastolic dysfunction. Exacerbation of their hypertension, a comorbidity highly prevalent in HFpEF, compromised renal function and structure similarly in normoglycemic obese female ZSF1 rats and hyperglycemic obese male ZSF1 rats.

Nguyen ITN, Cramer MJ, Joles JA, Verhaar MC. Renal injury in relation to obesity and the additive effect of hypertension in female and male obese and lean ZSF1 rats. Am J Physiol Renal Physiol. 2023 May 25. doi: 10.1152/ajprenal.00286.2022. Epub ahead of print. PMID: 37227224.