Output

Publications, presentations, dissertations and other public information generated in RECONNECT (2015-2020) and RECONNEXT (2021-2026)

Highlights

2023

2022


Output from RECONNECT

TitleAuthorsJournalDigital link
α-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes.Franssen C, Kole J, Musters R, Hamdani N, Paulus WJ.Circ. Heart Fail.https://www.ahajournals.org/doi/full/10.1161/circheartfailure.116.003626
What can we learn about treating heart failure from the heart’s response to acute exercise? Focus on the coronary microcirculation.Heinonen I, Sorop O, de Beer VJ, Duncker DJ, Merkus D.Appl Physiolhttps://journals.physiology.org/doi/full/10.1152/japplphysiol.00053.2015
Waist-hip ratio and Mortality in Heart Failure.Streng KW, Voors AA, Hillege JL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Lang CC.EJHFhttps://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.1244
Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review.Gohar A, de Kleijn DPV, Hoes AW, Rutten FH, Hilfiker-Kleiner D, Ferdinandy P, Sluijter JPG, den Ruijter HM.Vascul Pharmacolhttps://www.sciencedirect.com/science/article/pii/S1537189117304664?via%3Dihub
Vascular calcification associates with sex-specific vascular miRNA profiles in idiopathic atrial fibrillation patientsElton AMP Dudink, Barend W Florijn, Bob Weijs , Jacques MGJ Duijs, Justin GLM Luermans, Frederique ECM Peeters, Leon Schurgers, Joachim Wildberger, Uli Schotten, Roel Bijkerk, Harry JGM Crijns and Anton Jan van ZonneveldmicroRNAhttp://www.eurekaselect.com/167683/article
Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids.Zhou Z, Lankhuizen IM, van Beusekom HM, Cheng C, Duncker DJ, Merkus D.Front Pharmacol.https://www.frontiersin.org/articles/10.3389/fphar.2018.00255/full
Turning The Retrospectroscope On Heart Failure With Preserved Ejection Fraction.Paulus WJJ Card Fail.https://www.onlinejcf.com/article/S1071-9164(16)31157-5/fulltext
Trajectories of Changes in Renal Function in Patients with Acute Heart FailureBeldhuis IE, Streng KW, van der Meer P, ter Maaten JM, O’Connor CM, Metra M, Dittrich HC, Ponikowski P, Cotter G, Cleland JG, Davison BA, Givertz MM, Teerlink JR, Bloomfield DM, Voors AA, Damman K.J Card Fail.https://www.onlinejcf.com/article/S1071-9164(19)30070-3/fulltext
The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis.Bouthoorn S, Valstar GB, Gohar A, den Ruijter HM, Reitsma HB, Hoes AW, Rutten FHDiab Vasc Dis Res.https://journals.sagepub.com/doi/10.1177/1479164118787415
The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis.Wesseling M, Sakkers TR, de Jager SCA, Pasterkamp G, Goumans MJ.Vascul Pharmacolhttps://www.sciencedirect.com/science/article/pii/S1537189118300065?via%3Dihub
The microcirculation: a key player in obesity-associated cardiovascular disease.Sorop O, Olver DT, van de Wouw J, Heinonen I, Van Duin RW, Duncker DJ, Merkus DCardiovasc Reshttps://academic.oup.com/cardiovascres/article/113/9/1035/3803704
TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases.Pardali E, Sanchez-Duffhues G, Gomez-Puerto MC, Ten Dijke P.Int J Mol Sci.https://www.mdpi.com/1422-0067/18/10/2157
Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation.Oosterhuis NR, Bongartz LG, Verhaar MC, Cheng C, Xu YJ, van Koppen A, Cramer MJ, Goldschmeding R, Gaillard CA, Doevendans PA, Braam B, Joles JA.Acta Physiol (Oxf).https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.12829
Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-Derived Endothelial Cells In VitroVincent van Duinen, Wendy Stam, Viola Borgdorff, Arie Reijerkerk, Valeria Orlova, Paul Vulto, Thomas Hankemeier, Anton Jan van Zonneveld,JOVEhttps://www.jove.com/video/59678/standardized-scalable-assay-to-study-perfused-3d-angiogenic-sprouting
Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exerciseS.B. Bender, V.J. de Beer, D.L. Tharp, D.K. Bowles, M.H. Laughlin, D.Merkus, D.J. DunckerBasic Res Cardiolhttps://link.springer.com/article/10.1007%2Fs00395-016-0579-9
Recommended Heart Failure Medications and Adverse Drug Reactions in Women.Bots SH, den Ruijter HM.Circulationhttps://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.118.037585
Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure.Emmens JE, Ter Maaten JM, Damman K, van Veldhuisen DJ, de Boer RA, Struck J, Bergmann A, Sama IE, Streng KW, Anker SD, Dickstein K, Lang CC, Metra M, Samani NJ, Ng LL, Voors AA.Circ Heart Fail.https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118.005544
Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis.Bouthoorn S, Gohar A, Valstar G, den Ruijter HM, Reitsma JB, Hoes AW, Rutten FH; Queen of Hearts Consortium.Cardiovasc Diabetol.https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0690-3
Preeclampsia and coronary plaque erosion: Manifestations of endothelial dysfunction resulting in cardiovascular events in women.de Jager SCA, Meeuwsen JAL, van Pijpen FM, Zoet GA, Barendrecht AD, Franx A, Pasterkamp G, van Rijn BB, Goumans MJ, den Ruijter HM.Eur J Pharmacolhttps://www.sciencedirect.com/science/article/pii/S0014299917305903?via%3Dihub
Position paper of the European Society of Cardiology-working group of coronary pathophysiology and microcirculation: obesity and heart disease.Badimon L, Bugiardini R, Cenko E, Cubedo J, Dorobantu M, Duncker DJ, Estruch R, Milicic D, Tousoulis D, Vasiljevic Z, Vilahur G, de Wit C, Koller A.Eur Heart Jhttps://academic.oup.com/eurheartj/article/38/25/1951/3813124
Porcine models for studying complications and
organ crosstalk in diabetes mellitus.		S Renner, A Blutke, S Clauss, CA Deeg, E Kemter, D Merkus, R Wanke, and E Wolf,Cell Tissue Reshttps://link.springer.com/article/10.1007/s00441-019-03158-9
Phenotypic anti-angiogenic screening assay using iPSC derived endothelium in a perfused microfluidic 3D culture platformV. van Duinen, W. Stam, E. Mulder, F. Famili, A. Reijerkerk, P. Vulto, T. Hankemeier and A.J. van Zonneveld.IJMS 
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ.Circulationhttps://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.021884
Perturbations in Myocardial Perfusion and Oxygen Balance in Swine With Multiple Risk Factors: A Novel Model of Ischemia and No Obstructive Coronary Artery Diseasevan de Wouw J, Sorop O, van Drie RWA, van Duin RWB, Nguyen ITN, Joles JA, Verhaar MC, Merkus D, Duncker DJ.Basic Res Cardiolhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042191/
Perfused 3D angiogenic sprouting in a high-throughput in vitro platform.V. van Duinen, D. Zhu, C. Ramakers, A.J. van Zonneveld, P. Vulto and T. HankemeierAngiogenesishttps://link.springer.com/article/10.1007/s10456-018-9647-0
Outpatient treatment of worsening heart failure with
intravenous and subcutaneous diuretics: a systematic review of the literature.		Wierda E, Dickhoff C, Handoko ML, Oosterom L,
Kok WE, de Rover Y, de Mol BAJM, van Heerebeek L, Schroeder-Tanka JM.		ESC Heart Fail.https://pubmed.ncbi.nlm.nih.gov/32159279/
Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the communityA Gohar, R.F Kievit, G.B Valstar, A.W Hoes, E.E Van Riet, Y van Mourik, L.C Bertens, L.J Boonman-Winter, M.L Bots, H.M den Ruijter and F.H RuttenEur J Prev.Cardhttps://journals.sagepub.com/doi/10.1177/2047487318816774
OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis and elevated fillings pressures in a murine model for heart failure with a preserved ejection fraction.Van der Pol A, Gil A, Tromp J, Siljé HHW, van Veldhuisen DJ, Voors AA, Hoendermis ES, Grote Beverborg N, Schouten EM, de Boer RA, Bischoff R, van der Meer P.Cardiovasc Reshttps://academic.oup.com/cardiovascres/article/114/14/1871/5056075
Non-cardiac Comorbidities in Heart Failure with Reduced, Mid-range and Preserved Ejection Fraction.Streng KW, Nauta JF, Hillege JL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Voors AA.Int J Cardio in presshttps://www.internationaljournalofcardiology.com/article/S0167-5273(17)36744-X/fulltext
Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening.Sorop O, Heinonen I, van Kranenburg M, van de Wouw J, de Beer VJ, Nguyen TN, Octavia Y, van Duin RWB, Stam K, van Geuns RJ, Wielopolski PA, Krestin GP, van den Meiracker AH, Verjans R, van Bilsen M, Danser AHJ, Paulus WJ, Cheng C, Linke WA, Joles JA, Verhaar MC, van der Velden J, Merkus D, Duncker DJ.Cardiovasc Reshttps://academic.oup.com/cardiovascres/article/114/7/954/4844872
Mortality after hospital admission for heart failure: Improvement over time, equally strong in women as in men.Buddeke J, Valstar GB, van Dis I, Visseren FJ, Rutten FH, den Ruijter HM, Vaartjes I Bots ML, on behalf of the Queen of Hearts and RECONNECT investigators.BMC Public Healthhttps://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7934-3
Mildly increased renin expression in the absence of kidney injury in the murine trans aortic constriction modelWesseling M, Mulder E, Brans MAD, Bulthuis M, Pasterkamp G, Verhaar MC, van Goor H, Joles JA, de Jager SCAsubmitted to Cardiorenal medicine 
Microvascular Paradigm in Heart Failure With Preserved Ejection Fraction: A Quest for Proof of Concept.Waddingham MT, Paulus WJ.Circ. Heart. Fail.https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.117.004179
Lysyl Oxidase-Like 2 Is a Regulator of Angiogenesis Through Modulation of Endothelial-To-Mesenchymal Transitionde Jong OG, van der Waals LM, Kools FRW, Verhaar MC, van Balkom BWM.J Cell Physiol. 2019 Jul;234(7):10260-10269.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587725/
Long non-coding RNAs in heart failure: an obvious lnc.El Azzouzi H, Doevendans PA, Sluijter JP.Ann Transl Medhttp://atm.amegroups.com/article/view/10417/11061
Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction.Brandt MM, Nguyen ITN, Krebber MM, van de Wouw J, Mokry M, Cramer MJ,Duncker DJ, Verhaar MC, Joles JA, Cheng C.J Cell Mol Med. 2019https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14542
Innovations in approaches to remove uraemic toxins.Masereeuw R, Verhaar MC.Nat Rev Nephrol. 2020 May 7https://www.nature.com/articles/s41581-020-0299-0
Inflammation promotes vascular calcification by down-regulating BMPR2 and inducing Endothelial-to-mesenchymal transition.G. Sánchez-Duffhues, A.G de Vinuesa, M. E. Geerts, M.R. de Vries, S.G. T. Janson, H. van Dam, J. Lindeman, M.J. Goumans, P. ten Dijke.The Journal of Pathologyhttps://onlinelibrary.wiley.com/doi/full/10.1002/path.5193
Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1Pei J, Juni R, Harakalova M, Duncker DJ, Asselbergs FW, Koolwijk P, Hinsbergh VV, Verhaar MC, Mokry M, Cheng C.Toxinshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723868/
Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.van den Hoogen P, de Jager SCA, Huibers MMH, et al.J Cell Mol Med. 
Impaired kidney function is associated with intraplaque hemorrhage in patients undergoing carotid endarterectomy.Wesseling M, van Koeverden ID, van Lammeren GW, van der Laan SW, Haitjema S, de Vries JPM, den Ruijter HM, de Jager SCA, Hoefer I, Blankestijn P, Verhaar M, de Kleijn DPV, de Borst GJ, Pasterkamp GArtherosclerosishttps://www.atherosclerosis-journal.com/article/S0021-9150%2817%2931307-2/abstract
Immunomodulation in Heart Failure With Preserved Ejection Fraction: Current State and Future PerspectivesKessler EL, Oerlemans MIFJ, van den Hoogen P, Yap C, Sluijter JPG, de Jager SCAJ Cardiovasc Transl Reshttps://link.springer.com/article/10.1007%2Fs12265-020-10026-3
Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection FractionTromp J, Westenbrink BD, Ouwerkerk W, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Lang CC, Ng LL, Zannad F, Zwinderman AH, Hillege JL, van der Meer P, Voors AA.JACChttps://www.sciencedirect.com/science/article/pii/S073510971835407X?via%3Dihub
Hypertension in Dialysis Patients: A Consensus Document by the European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) and the Hypertension and the Kidney Working Group of the European Society of Hypertension (ESH)Sarafidis PA, Persu A, Agarwal R, Burnier M, de Leeuw P, Ferro CJ, Halimi JM, Heine GH, Jadoul M, Jarraya F, Kanbay M, Mallamaci F, Mark PB, Ortiz A, Parati G, Pontremoli R, Rossignol P, Ruilope L, Van der Niepen P, Vanholder R, Verhaar MC, Wiecek A, Wuerzner G, London GM, Zoccali C.Nephrol Dial Transplant. 2017 Apr 1;32(4):620-640.https://academic.oup.com/ndt/article/32/4/620/3069157
Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal playerWesseling M, de Poel JHC, de Jager SCAESC Heart failurehttps://onlinelibrary.wiley.com/doi/full/10.1002/ehf2.12728
Genome-wide analysis reveals unique chromatin signatures in myocardium of patients with aortic stenosis-induced chronic pressure overload.J.Y. Pei, M. Harakalova, T.A.Treibel, T. Lumbers, B.J. Boukens, I.R. Efimov, H. El Azzouzi, C.G.M. van Dijk, M.M. Krebber, H. den Ruijter, G. Pasterkamp, D.J. Duncker, E. Nieuwenhuis, R. de Weger, M.M. Huibers, A. Vink, J.H. Moore, J.C. Moon, M.C. Verhaar, M. Mokry, F.W. Asselbergs, C. Cheng.Submitted 
Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts*G. Sanchez-Duffhues, H. Mikkers, D. de Jong, K. Szuhai, T. J. de Vries, C. Freund, N. Bravenboer, R. J. J. van Es, J. C. Netelenbos, M-J. Goumans, E.M.W. Eekhoff, P. ten Dijke.Stem Cell Reshttps://www.sciencedirect.com/science/article/pii/S1873506119302697
Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure.Ter Maaten JM, Voors AA, Damman K, van der Meer P, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Navis G, Ng L, Ouwerkerk W, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, de Borst MH.Int J Cardiolhttps://www.internationaljournalofcardiology.com/article/S0167-5273(17)33894-9/abstract
Fibrates in hypertension: where do we stand?Gremmels H, Joles JA.J Hypertens.https://journals.lww.com/
FGF23 impairs peripheral microvascular function in renal failureVerkaik M, Juni RP, van Loon EPM, van Poelgeest EM, Kwekkeboom RFJ, Gam V, Richards WG, ter Wee PM, Hoenderop JG, Eringa EC, Vervloet, MGJ Physiol Heart Circ Physiol.https://journals.physiology.org/doi/full/10.1152/ajpheart.00272.2018
Experimental animal models of coronary microvascular dysfunction.Sorop O, van de Wouw J, Chandler S, Ohanyan V, Tune JD, Chilian WM, Merkus D, Bender SB, Duncker DJ.Cardiovasc Reshttps://academic.oup.com/cardiovascres/article/116/4/756/5700718
Estrogen
Contributions to Microvascular Dysfunction Evolving to Heart Failure With
Preserved Ejection Fraction.		Sickinghe AA, Korporaal SJA, den Ruijter HM, Kessler EL.Front Endocrinol (Lausanne).https://www.frontiersin.org/articles/10.3389/fendo.2019.00442/full
Epoetin Beta and C‐Terminal Fibroblast Growth Factor 23 in Patients With Chronic Heart Failure and Chronic Kidney DiseaseEisenga MF, Emans ME, van der Putten K, Cramer MJ, Diepenbroek A, Velthuis BK, Doevendans PA, Verhaar MC, Joles JA, Bakker SJL, Nolte IM, Braam B, Gaillard CAJM.J Am Heart Assoc. 2019 Aug 20;8(16):e011130.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.011130?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry.Sánchez-Duffhues G, García de Vinuesa A, Ten Dijke P.Dev Dynhttps://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/dvdy.24589
Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1Maarten M. Brandt, Christian G. M. van Dijk,Ihsan Chrifi, Heleen M. Kool, Petra E. Bürgisser, Laura Louzao‐Martinez, Jiayi Pei, Robbert J. Rottier, Marianne C.Verhaar, Dirk J. Duncker, Caroline ChengAngiohttps://link.springer.com/article/10.1007%2Fs10456-018-9625-6
Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contractionRio P. Juni, Rushd Al-Shama, Diederik W.D. Kuster, Jolanda van der Velden, Henrike M. Hamer, Marc G. Vervloet, Etto C. Eringa, Pieter Koolwijk, Victor W.M. van HinsberghKidney International 
Empagliflozin improves endothelial and cardiomyocyte
function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation.		Kolijn D, Pabel S, Tian Y, Lódi M, Herwig M, Carrizzo A, Zhazykbayeva S,
Kovács Á, Fülöp GÁ, Falcão-Pires I, Reusch PH, Van Linthout S, Papp Z, van Heerebeek L, Vecchione C, Maier LS, Ciccarelli M, Tschöpe C, Mügge A, Bagi Z, Sossalla S, Hamdani N.		Cardiovascular Researchhttps://pubmed.ncbi.nlm.nih.gov/32396609/
Empagliflozin for Heart Failure with Preserved Ejection Fraction: targeting endothelial cell-cardiomyocyte interaction.Juni R, Kuster DWD, Goebel M, Helmes M, van der Velden J, Musters RJ, Koolwijk P, Paulus WJ, van Hinsbergh VWM.JMCChttps://www.jmmc-online.com/article/S0022-2828(18)30249-9/abstract
Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial CellsLaween Uthman-Anna Homayr, Rio P Juni, Eva L Spin, Raphaela Kerindongo, Marleen Boomsma, Markus W Hollmann, Benedikt Preckel, Pieter Koolwijk, Victor W M van Hinsbergh, Coert J Zuurbier, Martin Albrecht, Nina C WeberCell Physiol Biochemhttps://pubmed.ncbi.nlm.nih.gov/31724838/?from_term=juni+r&from_pos=2
Efficient selective screening for heart failure in elderly men and women from the community: A diagnostic individual participant data meta-analysis.Kievit RF, Gohar A, Hoes AW, Bots ML, van Riet EE, van Mourik Y, Bertens LC, Boonman-de Winter LJ, den Ruijter HM, Rutten FH; Queen of Hearts and RECONNECT consortium.Eur J Prev Cardiol.https://journals.sagepub.com/doi/10.1177/2047487317749897
Ebola hemorrhagic shock syndrome-on-a-chipAbidemi Junaid1,*, Huaqi Tang1,*, Petra Wuelfroth2, Vincent van Duinen1,3,4, Thomas Hankemeier1, Anton Jan van Zonneveld3,4, Alireza Mashaghi1iSciencehttps://www.sciencedirect.com/science/article/pii/S2589004219305103
Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin DysbalanceKhairoun M, van den Heuvel M, van den Berg BM, Sorop O, de Boer R, van Ditzhuijzen NS, Bajema IM, Baelde HJ, Zandbergen M, Duncker DJ, Rabelink TJ, Reinders ME, van der Giessen WJ, Rotmans JI.PlosOnehttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121555
Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction.van den Dorpel MMP, Heinonen I, Snelder SM, Vos HJ, Sorop O, van Domburg RT, Merkus D, Duncker DJ, van Dalen BM.Int J CV Imaginghttps://link.springer.com/article/10.1007/s10554-017-1287-8
Distinct Myocardial Targets for Diabetes Therapy in Heart Failure With Preserved or Reduced Ejection Fraction.Paulus WJ, Dal Canto EJACC Heart Fail.https://www.sciencedirect.com/science/article/pii/S2213177917305334?via%3Dihub
Distinct endothelial cell responses in the heart and kidney microvasculature characterize the progression of heart failure with preserved ejection fraction in the obese ZSF1 rat with cardiorenal metabolic syndrome.van Dijk CG, Oosterhuis NR, Xu YJ, Brandt M, Paulus WJ, van Heerebeek L, Duncker DJ, Verhaar MC, Fontoura D, Lourenço AP, Leite-Moreira AF, Falcão-Pires I, Joles JA, Cheng C.Circulation HFhttps://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.115.002760
Dissociation Between Hypertrophy and Fibrosis in the Left Ventricle Early After Experimental Kidney TransplantationNR Oosterhuis, DA Papazova, M Mokry, MJ Cramer, R Bleys, C Cheng, JA Joles, MC VerhaarJ Hypertens.https://journals.lww.com/jhypertension/
Dissecting recipient from donor contribution in experimental kidney transplantation: focu on endothelial proliferation and inflammationDA papazova, MM Krebber, NR Oosterhuis, H Gremmels, AD van Zuilen, JA Joles, MC VerhaarDis Models MEchhttps://dmm.biologists.org/content/11/7/dmm035030
Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic.Valstar GB, Bots SH, Groepenhoff F, et al.BMJ Open 
Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.Aragonez CG, de Beer VJ, Tharp DL, Bowles DK, Laughlin MH, Merkus D, Duncker DJ, Bender SB.Microcirculationhttps://onlinelibrary.wiley.com/doi/abs/10.1111/micc.12539
Diastole Tracks Cardiometabolic Risk.Paulus WJ, Dal CantoJACC Heart Fail.https://heartfailure.onlinejacc.org/content/6/4/326.abstract
Diabetic nephropathy alters the distribution of circulating angiogenic miRNAs over extracellular vesicles, HDL and Ago-2Barend W. Florijn, Jacques M.G.J. Duijs, Johannes H. Levels, Geesje M. Dallinga-Thie, Yanan Wang, Anita N. Boing, Wendy Stam, Ronald W.A.L. Limpens, Yu Wah Au, Rienk Nieuwland, Ton J. Rabelink, Marlies E.J. Reinders, Anton Jan van Zonneveld and Roel BijkerkDiabeteshttps://diabetes.diabetesjournals.org/content/68/12/2287
Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial CellsG. Sánchez-Duffhues, E. Williams, P. Benderitter, V. V. Orlova, M. van Wijhe, A. Garcia de Vinuesa, G. Kerr, J. Caradec, H.C. de Boer, M-J. Goumans, E. M. W. Eekhoff, A. Morales-Piga, J. Bachiller-Corral, P. Koolwijk, A.N. Bullock, J. Hoflack, P. ten Dijke.JBMR Plushttps://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbm4.10230
Coronary microvascular dysfunction in cardiovascular disease: lessons from large animal modelsSorop O, van de Wouw J, Merkus D, Duncker DJBookchapter: Springer Naturehttps://link.springer.com/chapter/10.1007/978-3-030-28199-1_2
Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia.Sorop O, van den Heuvel M, van Ditzhuijzen NS, de Beer VJ, Heinonen I, van Duin RW, Zhou Z, Koopmans SJ, Merkus D, van der Giessen W, Danser AH, Duncker DJ.Am J Physiol Heart Circ Physiol.https://journals.physiology.org/doi/full/10.1152/ajpheart.00458.2015
Connecting heart failure with preserved ejection fraction and renal dysfunction – the role of endothelial dysfunction and inflammationTer Maaten JM, Damman K, Verhaar MC, Paulus WJ, Duncker DJ, Cheng C, van Heerebeek L, Hillege HL, Lam CS, Navis G, Voors AA.EUR JHFhttps://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.497
Comparing biomarker profiles of patients with heart failure: Atrial fibrillation versus Sinus rhythm and reduces versus preserved ejection fraction.Santema BT, Kloosterman M, van Gelder IC, Mordy I, Lang CC, Lam CSP, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege JL, ter Maaten JM, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Rienstra M, Voors AA.Eur Heart Jhttps://academic.oup.com/eurheartj/article/39/43/3867/5077588
CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctionsI Chrifi, L. Louzao-Martinez, MM Brand, CGM van Dijk, P E Burgisser, C Zhu, JM Kris, MC Verhaar, DJ Duncker, C Cheng.Angiogenesishttps://link.springer.com/article/10.1007%2Fs10456-018-9638-1
CMTM3 mediates angiogenesis by regulating cell surface availability of Ve-cadherin in endothelial adherens junctions.Chrifi I, Louzao-Martinez L, Brandt M, van Dijk C, Burgisser P, Zhu C, Kros J.M, Duncker D.J, Cheng C.ATVBhttps://www.ahajournals.org/doi/10.1161/ATVBAHA.116.308792
Chronic Kidney Disease as a Risk Factor for HFpEF: a Focus on Microcirculatory Factors and Therapeutic Targets.van de Wouw J, Broekhuizen M, Sorop O, Danser AHJ, Verhaar MC, Joles JA, Duncker DJ, Merkus DFrontiers in Physiologyhttps://www.frontiersin.org/articles/10.3389/fphys.2019.01108/full
Chromatin Conformation Links Distal Target Genes to CKD Loci.MM Brandt, CA Meddens, L Louzao-Martinez, DJ Duncker, MC Verhaar, JA Joles, M Mokry, C ChengJASNhttps://jasn.asnjournals.org/content/29/2/462.abstract
Characteristic adaptations of the extracellular matrix in dilated cardiomyopathyL Louzao-Martineza, A Vink, M Harakalova, FW Asselbergs, MC Verhaar, C Cheng.IJCARDhttps://www.internationaljournalofcardiology.com/article/S0167-5273(16)31259-1/fulltext
Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangementHeinonen I, Sorop O, Van Dalen B, Wüst R, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, and Duncker DJSci Rep 
CECR1-mediated crosstalk between macrophages and vascular mural cells promotes neovascularization in malignant glioma.C Zhu, I Chrifi, D Mustafa, M vd Weiden, PJM Leenen, DJ Duncker, JM Kros, C Cheng.ONCOGENEhttps://www.nature.com/articles/onc2017145
Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws.van Essen GJ, Te Lintel Hekkert M, Sorop O, Heinonen I, van der Velden J, Merkus D, Duncker DJ.Sci Rephttps://www.nature.com/articles/s41598-017-18775-z
Cardiorenal disease connection during post-menopause: The protective role of estrogen in uremic toxins induced microvascular dysfunction.Pei J, Harakalova M, den Ruijter H, Pasterkamp G, Duncker DJ, Verhaar MC, Asselbergs FW, Cheng C.IJCARDhttps://www.internationaljournalofcardiology.com/article/S0167-5273(17)31609-1/fulltext
Cardiac Shear Wave Velocity Detection in the Porcine HeartVos HJ, van Dalen BM, Heinonen I, Bosch JG, Sorop O, Duncker DJ, van der Steen AF, de Jong N.Ultrasound Med Biolhttps://doi.org/10.1016/j.ultrasmedbio.2016.11.015
Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by EmpagliflozinRio P Juni , Diederik W D Kuster , Max Goebel, Michiel Helmes, René J P Musters, Jolanda van der Velden, Pieter Koolwijk, Walter J Paulus , Victor W M van HinsberghJACC Basic Transl Scihttps://www.sciencedirect.com/science/article/pii/S2452302X1930138X?via%3Dihub
Both Male and Female Obese ZSF1 Rats Develop Cardiac Dysfunction in Obesity-Induced Heart Failure With Preserved Ejection FractionNguyen ITN, Brandt MM, van de Wouw J, van Drie RWA, Wesseling M, Cramer MJ, de Jager SCA, Merkus D, Duncker DJ, Cheng C, Joles JA, Verhaar MCPlos Onehttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232399
Bone morphogenetic protein receptors: structure, function and targeting by selective small molecule kinase inhibitorsGonzalo Sanchez-Duffhues, Eleanor Williams, Marie-José Goumans, Carl-Henrik Heldin, Peter Ten DijkeBoneIn press
Biomarkers of renal function: towards clinical actionability.Binnenmars SH, Hijmans RS, Navis G, De Borst MHClin Pharmacolhttps://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/cpt.765
BiomarCaRE
Consortium. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in
Europe: Results From the BiomarCaRE Consortium		Magnussen C, Niiranen TJ, Ojeda FM, Gianfagna F, Blankenberg S, Vartiainen E, Sans S, Pasterkamp G, Hughes M, Costanzo S, Donati MB, Jousilahti P, Linneberg A, Palosaari T, de Gaetano G, Bobak M, den Ruijter HM, Jørgensen T, Söderberg S, Kuulasmaa K, Zeller T, Iacoviello L, Salomaa V, Schnabel RBJACC Heart Failhttps://www.sciencedirect.com/science/article/pii/S2213177918306905?via%3Dihub
An End-User Perspective on Organ-on-a-Chip: Assays and Usability Aspects.Abidemi Junaid, Alireza Mashaghi, Thomas Hankemeier, Paul VultoCOBMEhttps://www.sciencedirect.com/science/article/pii/S246845111730003X
Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement.Zhou Z, Sorop O, de Beer, VJ, Heinonen I, Cheng C, Dansel AHJ, Duncker DJ, Merkus DPurinergic Signallinghttps://link.springer.com/article/10.1007/s11302-017-9563-6
Adverse Drug Reactions to
Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the
Literature.		Bots SH, Groepenhoff F, Eikendal ALM, Tannenbaum C, Rochon PA, Regitz-Zagrosek
V, Miller VM, Day D, Asselbergs FW, den Ruijter HM.		JACC Heart Fail.https://www.sciencedirect.com/science/article/pii/S2213177919300307
Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression.Zhu C, Mustafa D, Zheng PP, van der Weiden M, Sacchetti A, Brandt M, Chrifi I, Tempel D, Leenen PJM, Duncker DJ, Cheng C, Kros JM.NEURO ONCOLhttps://academic.oup.com/neuro-oncology/article/19/5/648/2798200
A randomised comparison of the effect of haemodynamic
monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure : Design and rationale of the MONITOR HF multicentre randomised clinical trial.		Brugts JJ, Veenis JF, Radhoe SP, Linssen GCM, van Gent M, Borleffs CJW,
van Ramshorst J, van Pol P, Tukkie R, Spee RF, Emans ME, Kok W, van Halm V, Handoko L, Beeres SLMA, Post MC, Boersma E, Lenzen MJ, Manintveld OC, Koffijberg H, van Baal P, Versteegh M, Smilde TD, van Heerebeek L, Rienstra M, Mosterd A, Delnoy PPH, Asselbergs FW, Brunner-La Rocca HP, de Boer RA.		Netherlands Heart Journalhttps://pubmed.ncbi.nlm.nih.gov/31776915/
A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients With Severe Limb IschemiaGremmels H, Teraa M, de Jager SCA, Pasterkamp G, de Borst GJ, Verhaar MCScientific Reportshttps://www.nature.com/articles/s41598-019-47217-1

2023

  • BHF Center of Excellence, Oxford BHF CRE Principal Investigators’ emerging theme evening, University of Oxford. Lecture titled: “Coronary Microvascular Dysfunction in Ischaemic Heart Disease: matching in vivo and ex vivo function.”

 

2022

  • Frontiers in Cardiovascular Biomedicine Congress held in Budapest. Presentation titled: “Experimental models of coronary microvascular dysfunction: a translational view”.
  • European Society of Cardiology Congress in Barcelona. Session ‘Asymptomatic Atherosclerotic Coronary Artery Disease’. Presentation titled: “Non-invasive Testing for Endothelial Function: Physiology Predates Anatomy”.
  • Europhysiology Meeting in Copenhagen. Presentation titled: “Microvascular physiology in health and disease: lessons from large animal models”.
  • Eurothrombosis & EuroVessels 2022 in Lisbon. Presentation titled: “Role of coronary microvascular dysfunction in cardiovascular disease”.
  • Netherlands Society for Cardiology (NVvC) in Papendal Sports Center, Arnhem. Presentation titled: “Gender and cardiovascular disease: a translational view”.
  • 12thCardiovascular Research Days & 28th Krakow Conference on Endothelium in Krakow. Keynote Lecture titled: “Coronary microvascular endothelial dysfunction in ischaemic heart disease”.

 

2021

  • Experimental Biology Meeting 2021 Virtual – Gabor Kaley Memorial Lecture Award: “The Coronary Microvasculature: Small Vessels with Big Responsibilities”.

 

 

Output from RECONNECT

MeetingDateTitlePI group (+ presenter)
Zurich, Universtats spitalJuly-05MicroRNAs in kidney health and diseaseAnton Jan Zonneveld
Cardiorenal seminar AachenJuly-05Tracking the cardiorenal functions of miR-132Anton Jan Zonneveld
Cardio Vascular Conference (CVC) 2016 Noordwijkerhout, NetherlandsFebruary-16A human microvascular organ-on-a chip platform to assess circulating factors associated with microvascular destabilization in patients with chronic kidney disease,Abidemi Junaid, Janine van Gils, Vincent van Duinen, Thomas Hankemeier and Anton Jan van Zonneveld
FCVB, Florence, Italy.July-16Vascular Remodeling in ObesityD. Duncker
FCVB, Florence, Italy.July-16Multiple co-morbidities produce left ventricular diastolic dysfunction in a large animal modelDirk Duncker (O. Sorop)
Paris EURECA-m CME cardiorenal Course program. Faculté de Médecine Lariboisière, Paris, France.September-16 ‘Renal connection to microvascular disease and heart failure with preserved ejection fraction’M. Verhaar
NHS PapendalOctober-16Poster: The Pathogenic Role of GDF-15 on Microvascular Dysfunction in Cardiorenal SyndromeMarian Wesseling
Dutch-German Join Vascular Biology Meeting, Leiden, The Netherlands.November-16Poster: Lack of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload in miceS.C.A. de Jager (J.J. de Haan)
Experimental BiologyApril-17 Poster presentation Increased NO Sensitivity is Associated with Maintained Coronary Microvascular cGMP-PDE5 Signaling in Exercising Swine with Multiple Co-MorbiditiesDirk Duncker (R. van Drie)
Experimental BiologyApril-17 Poster presentation Multiple co-morbidities have detrimental effects on myocardial function and perfusion in a large animal  model of diastolic dysfunctionDirk Duncker (O. Sorop)
Experimental BiologyApril-17 Poster presentation Loss of Nitric Oxide Contributes to Perturbations in Myocardial Oxygen Balance in Exercising Swine with Multiple ComorbiditiesDirk Duncker (J. van de Wouw)
ESC Heart Failure, Paris, FrApril-17Poster: Lack of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload in miceS.C.A. de Jager
European Society for Vascular Surgery. Leiden. NL.May-17Selected oral communication: Inflammation-induced EndMT facilitates endothelial calcificationMarie-Jose Goumans (G. Sanchez-Duffhues)
LICR-LUMC TGF-β Meeting. Uppsala, SW.August-17Selected poster: Inflammation-induced EndMT facilitates BMP-mediated vascular calcification in a BMP type II receptor (BMPR2) dependent manner. *Best poster prize award.Marie-Jose Goumans (G. Sanchez-Duffhues)
ESCSeptember-17Poster presentation Alterations in coronary microvascular NO signaling in exercising swine with multiple comorbiditiesDirk Duncker (O. Sorop)
ESCSeptember-17Poster presentation Exacerbated Pulmonary Hypertension and Ventilation Perfusion Mismatch during Exercise in
a Swine Model of Chronic Thromboembolic Pulmonary Hypertension		D. Merkus
ESCSeptember-17Invited Lecture  Pathophysiology of coronary flow and no-reflowDirk Duncker
ESCSeptember-17 Invited Lecture State of the Art: endothelial function and the microcirculationDirk Duncker
27th MGC Symposium. Rotterdam, NL.September-17Lecture: Endothelial-to-mesenchymal transition in human diseaseMarie-Jose Goumans (G. Sanchez-Duffhues)
Papendal PhD course 2017 – Presentation PrizeOctober-17Oral presentation Multiple co-morbidities have detrimental effects on myocardial function and perfusion in a large animal model of diastolic dysfunctionDirk Duncker (J. van de Wouw)
CVON PHAEDRA Fall Meeting. The Hague. NL.October-17Invited speaker: Inflammation and endothelial-to-mesenchymal transitionMarie-Jose Goumans (G. Sanchez-Duffhues)
NHS PapendalOctober-17Poster: Endothelial-to-mesenchymal transition in cardiorenal syndromeMarian Wesseling
8th Rembrandt Symposium. Noordwijkerhout. NL.November-178th Rembrandt Symposium. Noordwijkerhout. NL.Marie-Jose Goumans (G. Sanchez-Duffhues)
Frontiers in Cardiovascular Biology. VienaApril-18Selected poster: Inflammation-induced EndMT facilitates BMP-mediated vascular calcification in a BMP type II receptor (BMPR2) dependent manner. *Best poster prize award.Marie-Jose Goumans (G. Sanchez-Duffhues)
Frontiers in Cardiovascular Biology, VienaApril-18Poster: The absence of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overloadS.C.A. de Jager (M. Wesseling)
2ndTranslational Cardiovascular Research Meeting, Netherlands Heart Institute, Utrecht, The Netherlands.June-18Poster presentation Multiple Comorbidities Lead to Impaired Myocardial Oxygen Balance and Ischemia in Exercising SwineDaphne Merkus (J. van de Wouw)
2ndTranslational Cardiovascular Research Meeting, Netherlands Heart Institute, Utrecht, The Netherlands.June-18Selected poster presentation, Cardiac microvascular endothelial cell regulation on cardiomyocyte contraction and relaxation: the role of inflammatory activation and empagliflozin treatment (moderated poster presentation)Victor van Hinsbergh
International Vascular Biology Meeting, Helsinki, Finland.June-18Poster presentation, Cardiac microvascular endothelial cells improve cardiomyocyte function: the role of nitric oxide and empagliflozin treatmentVictor van Hinsbergh
FCVBJuly-18Poster Presentation Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbiditiesDirk Duncker (O. Sorop)
FCVBJuly-18Poster Presentation Maintained cGMP-PDE5 signaling in coronary microvascular of swine with multiple co-morbiditiesDirk Duncker (R. van Drie)
FCVBJuly-18Poster Presentation Loss of Nitric Oxide Contributes to Perturbations in Myocardial Oxygen Balance in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (J. van de Wouw)
FCVBJuly-18Invited Lecture Exercise and the coronary circulation in health and diseaseDirk Duncker
 International Society for Heart Research European Section, Amsterdam, The Netherlands.July-18Oral and poster presentation, Empagliflozin for heart failure with preserved ejection fraction: targeting cardiac endothelial cell-cardiomyocyte interactionVictor van Hinsbergh
ISHR (Poster price)July-18Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (J. van de Wouw)
ESCAugust-18Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (J. van de Wouw)
12th BMP International Conference. Tokyo, JP.October-18Selected oral presentation: Identification of Novel Macrocyclic ALK2 inhibitors for Fibrodysplasia ossificans progressiva using patient-derived endothelial colony forming cellsMarie-Jose Goumans (G. Sanchez-Duffhues)
Dutch-German Join Vascular Biology Meeting, Amsterdam, The Netherlands.November-18Poster presentation,
The role of pro-inflammatory stimulation and Empagliflozin treatment		Victor van Hinsbergh
AHANovember-18Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (J. van de Wouw)
DEBSNovember-18Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (J. van de Wouw)
AHANovember-18Poster presentation, Alterations in ROS-NO signaling in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (O. Sorop)
Dutch German Vascular Biology meeting. Amsterdam, NL.November-18Selected poster: Identification of Novel Macrocyclic ALK2 inhibitors for Fibrodysplasia ossificans progressiva using patient-derived endothelial colony forming cellsMarie-Jose Goumans (G. Sanchez-Duffhues)
DZHK-Munich Heart AllianceFebruary-19Invited oral presentation: Cardiac changes in swine models of left and right heart diseaseDaphne Merkus
Dutch German Molecular Cardiology meeting. Göttingen, GE.March-19Selected poster: Inflammation-induced EndMT facilitates BMP-mediated vascular calcification in a BMP type II receptor (BMPR2) dependent manner. *Best poster prize award.Marie-Jose Goumans (G. Sanchez-Duffhues)
Dutch-German Cardiovascular Joint Meeting, Gottingen, GermanyMarch-19Cardiac microvascular endothelial cells improve cardiomyocyte contractilefunction: The role of pro-inflammatory stimulation and Empagliflozin treatment (poster presentation)Victor van Hinsbergh (+ Rio Juni)
Experimental BiologyApril-19Poster presentation, Alterations in ROS-NO signaling in Exercising Swine with Multiple ComorbiditiesDirk Duncker (O. Sorop)
Experimental BiologyApril-19Poster presentation Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple ComorbiditiesDaphne Merkus (J. van de Wouw)
Experimental BiologyApril-19Poster presentation Limited synergy between major risk factors obesity and hypertension in development of HFpEFC. Cheng and Daphne Merkus (M. Brandt)
Experimental BiologyApril-19Poster presentation Pulmonary vascular disease in swine model with multiple comorbiditiesDaphne Merkus (J. Steenhorst)
UMCU Medical Physiology group, invited lectureApril-19Invited speaker: Growth Differentiation Factor 15 in cardiovascular disease: innocent bystander or major culprit?S.C.A. de Jager
European Society of Microcirculation and European Vascular Biology Organization joined Meeting, Maastricht, The Netherlands (Best abstract)April-19Cardiac microvascular endothelial cells improve cardiomyocyte contractilefunction: The role of pro-inflammatory stimulation and Empagliflozin treatment (poster presentation, best abstract)Victor van Hinsbergh (+ Rio Juni)
ECSM 2019June-19Invited oral presentation: Myocardial perfusion and oxygenation durig exercise in health and diseaseDaphne Merkus
International Society of Heart Research World Congress, Beijing, ChinaJune-19Empagliflozin Ameliorates Uremia-Induced Oxidative Damage in Cardiac Microvascular Endothelial Cells (poster presentation, HFpEF session chairman)Victor van Hinsbergh (+ Rio Juni)
Society for Heart and Vascular Metabolism Meeting, Amsterdam, The NetherlandsJune-19Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function is Impaired by Inflammation and Restored by Empagliflozin (poster presentation)Victor van Hinsbergh (+ Rio Juni)
Physiology 2019July-19Invited oral presentation: Coronary microcirculation in left and right heart failureDaphne Merkus
Amsterdam Cardiovascular Science Symposium, Amsterdam, The NetherlandsJuly-19Cardiac microvascular endothelial cells improve cardiomyocyte contractilefunction: The role of pro-inflammatory stimulation and Empagliflozin treatment (poster presentation)Victor van Hinsbergh (+ Rio Juni)
ESC-Best of Cardiovascular ResearchSeptember-19Invited oral presentation in symposium ‘Best of Cardiovascular Research’: Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening.DJ Duncker
German Vascular Biology Meeting, Heidelberg, GermanyOctober-19Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function is Impaired by Inflammation and Restored by Empagliflozin (oral presentation)Victor van Hinsbergh (+ Rio Juni)
Rembrandt Meeting, Noordwijkerhout, The NetherlandsNovember-19Empagliflozin Ameliorates Uremia-Induced Oxidative Damage in Cardiac Microvascular Endothelial Cells (oral/poster presentation)Victor van Hinsbergh (+ Rio Juni)
MDR Annual Meeting 2019December-19A multiorgan-on-a-chip diabetic nephropathy model for medium-high throughput screening of candidate therapies for kidney regenerationMC Verhaar (V. Nguyen)
UMC Utrecht, Research ColloquiumFebruary-20Invited speaker: GDF15 and endoMT: Mediating vascular dysfunction in heart failure?Marian Wesseling
Dutch Physiology Day, Utrecht, The NetherlandsFebruary-20Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Uremic Serum and Restored by Empagliflozin (oral presentation)Victor van Hinsbergh (+ Rio Juni)
Human Disease Model Technology annual meeting, Rotterdam, The NetherlandsFebruary-20Cardiac Microvascular Endothelial Enhancement Of Cardiomyocyte Function Is Impaired By Uremic Serum And Restored By Empagliflozin (oral presentation)Victor van Hinsbergh (+ Rio Juni)
Dutch German Meeting of Molecular cardiology (did not take place)March-20large animal models of Cardiorenal syndromeDaphne Merkus
Experimental Biology 2020-Online CongressApril-20Gabor Kaley Memorial Lecture Award’ winner and symposium organizer The Coronary Microvasculature: Small Vessels with Big ResponsibilitiesDirk Duncker
Experimental Biology 2020-Online CongressApril-20Oral presentation Diabetic metabolic dysregulation and chronic kidney disease induce specific perturbations in coronary microvascular function in swineDirk Duncker (O. Sorop)
Experimental Biology 2020-Online CongressApril-20Oral presentation Impaired Oxygenation of the Right Ventricle during Development of Pulmonary Hypertension in Swine is not due to Loss of Nitric OxideDaphne Merkus
Amsterdam UMC-VU Biomedical Sciences LectureApril-20Oral presentation Myocardial perfusion in health and diseaseDirk Duncker (O. Sorop)
FCVB 2020 -cancelledApril-20Accepted poster presentation Pulmonary vascular disease in a swine model of chronic kidney disease and metabolic derangementDaphne Merkus (J. Steenhorst)
FCVB 2020 -cancelledApril-20Accepted poster presentation Increased oxidative stress alters coronary microvascular tone in exercising swine with multiple comorbiditiesDirk Duncker (O. Sorop)
FCVB 2020 -cancelledApril-20Accepted poster presentation Myocardial perfusion abnormalities and anaerobic metabolism in exercising swine with multiple comorbidities due to loss of nitric oxideDirk Duncker (J. van de Wouw)
American Diabetes Association 80th scientific session (On-line)June-20Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Uremic Serum and Restored by Empagliflozin (poster presentation)Victor van Hinsbergh (+ Rio Juni, Etto Eringa)
ESC 2020September-20Accepted poster presentation Coronary microvascular dysfunction results in impaired coronary flow reserve and altered oxygen balance in a swine model of INOCA with multiple risk factorsDirk Duncker (O. Sorop)
Frontiers in Cardiovascular Biology, Florence, Itjuly-2016Poster: Lack of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload in miceS.C.A. de Jager
ISHRJuly-2018Poster presentation, Alcohol Consumption and Risk of New Onset Heart Failure in Patients with Type 2 Diabetes MellitusG Navis (SH Binnenmars)
RECONNECT summerschoolJune 2019CDK-HFpEF Interactions: a Platform for in vitro SimulationMC Verhaar (B.W.M. van Balkom)
ESC summerschooljune-2017Poster: Endothelial-to-mesenchymal transition in cardiorenal syndromeMarian Wesseling
UMCG Groningen, NLjune-2018Invited Lecture: Growth Differentiation Factor 15 in cardiovascular disease: innocent bystander or major culprit?S.C.A. de Jager
3th Translational Cardiovascular meeting. Utrecht, NLjune-2019Poster: The absence of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload via BMP signallingS.C.A. de Jager (M. Wesseling)
YOUNG TALENT   
poster presentatie EB2019, Orlando2019Limited synergy of obesity and hypertension, prevalent risk factors in onset and
progression of heart failure with preserved ejection fraction		M. Brandt
MDR Annual Meetingdec-19A multiorgan-on-a-chip diabetic nephropathy
model for medium-high throughput screening of candidate therapies for kidney regeneration		V. Nguyen
RECONNECT summerschoolJune-2019CDK-HFpEF Interactions: a Platform for in vitro SimulationB. van Balkom
RECONNECT MeetingJune-2019Determining the role of uremic toxins
on cardiac electrophysiology and arrhythmias
during chronic kidney disease – An Update		W. Van Ham
RECONNECT Meeting Summerschool1-9-2019Determining the role of uremic toxins
on cardiac electrophysiology and arrhythmias
during chronic kidney disease		W. Van Ham
Dutch German Joint Meeting of Molecular CardiologyMarch-2020Determining the role of uremic toxins
on cardiac electrophysiology and arrhythmias
during chronic kidney disease		W. Van Ham
RECONNECT summerschoolsep-19Single-cell RNA sequencing approach to map perivascular pericytes transition
to myofibroblasts during the development of HFpEF in ZSF1 rat heart		Ch. Van Dijk
Gordon Research Conference in Epigenetic Regulation
of Cardiovascular Disease, Hong Kong		May-2019 The novel lncRNA Titin antisense-1 shows promise as a circulating biomarker
and key mediator of heart failure with preserved ejection fraction pathophysiology in females		E.L. Robinson
British Society for Cardiovascular Research
Heart Failure meeting Cambridge, UK.		sep-19 A NOVEL REGULATORY LONG NON-CODING RNA EXHIBITS
SEX DIFFERENCES IN HEART FAILURE WITH PRESERVED EJECTION FRACTION		E.L. Robinson
International Society of Heart
Failure Research (ISHR)		2019 A NOVEL REGULATORY LONG NON-CODING RNA EXHIBITS
SEX DIFFERENCES IN HEART FAILURE WITH PRESERVED EJECTION FRACTION		E.L. Robinson
HFA Winter meetng Invited talk
Les Diablerets, Switzerland.		January-2019TTN-an.sense-1 as a sex-specific biomarker and novel molecular
target for therapy in HFpEF		E.L. Robinson
ISHR Cardiovascular webinar series April 2020TTN-an.sense-1 as a sex-specific biomarker and novel molecular
target for therapy in HFpEF		E.L. Robinson
ISHR-ES/SERVIER meetingFebruary-2018Energy insufficiency-mediated ADP elevations as cause
of diastolic dysfunction		V. Sequeira
RECONNECT summerschoolsep-19Energy insufficiency-mediated ADP elevations as cause of diastolic dysfunctionV. Sequeira
34th ISHR-European Section MeetingJuly-2017Energy insufficiency-mediated ADP elevations as cause of diastolic dysfunctionV. Sequeira
10th Asia Pacific Heart Rhythm Society Meetingsep-17Enhancing mitochondrial bioenergetics with SS31 recovers ventricular conduction abnormalities
caused by energy-deprivation in a cTnT HCM mouse		V. Sequeira
Annual meeting of the Working Groups on Myocardial
Function and Cellular Biology of the Heart of the ESC		May-2017Energy insufficiency in human hypertrophic cardiomyopathy caused by depressed
energy-buffering systems		V. Sequeira
Amsterdam Cardiovascular Sciences Symposiumapr-17Energy insufficiency-mediated ADP elevations as cause of diastolic heart failureV. Sequeira

 

 

 

Output from RECONNECT

Name

Title

Date

Koen Streng

Non-cardiac comorbidities in heart failure with preserved ejection fraction

12-jun-19

Marian Wesseling

Connecting vascular inflammation and endothelial
dysfunction in the cardiorenal axis

20-okt-20

Gideon Valstar

Left Ventricular Diastolic Dysfunction towards a
HELPFul role for biomarkers

17-nov-20

Jens van de Wouw

Distinctive Alterations in Microvascular Function
due to Multiple Common Morbidities

14-dec-20

Isabel Nguyen

Comorbidities in the Cardiorenal Syndrome

2021

Chris van Dijk

nog niet bekend

2021

Abidemi Junaid

Microengineered Human Blood Vessels For Next
Generation Drug Discovery

 

 

 

Output from RECONNECT

  • Prognose na ziekenhuisopname voor hartfalen. Buddeke J, Valstar GB, van Dis I, Visseren FL, Bots ML, den Ruijter HM, Vaartjes I. Hart- en vaatziekten in Nederland 2017: Cijfers over leefstijl, risicofactoren, ziekte en sterfte. Den Haag: Hartstichting, 2017:55-64. (PDF)
  • Kerncijfers over hart- en vaatziekten. De Boer AR, van Dis I, Vaartjes I, Bots ML. Hart- en vaatziekten in Nederland 2019: 25 jaar cijfers over incidentie, prevalentie, ziekte en sterfte. Den Haag: Hartstichting, 2019; 51-78. (PDF)
 
Non-scientific presentations

Meeting

Date

Title

PI group (+ presenter)

Visit Patient association CKD and Heart Failure at ErasmusMC

December-16

Research Reconnect Consortium

Dirk Duncker (O. Sorop, M. Brandt)

Visit prof. G. Kararigas Univ Charite Berlin

June-17

Research Reconnect Consortium

Dirk Duncker (O. Sorop, J. van de Wouw)

Visit prof. J. Daemen Amsterdam UMC

November-17

Three common comorbidities and their effect on the (coronary) microcirculation

Dirk Duncker (J. van de Wouw)

Visit prof. R. Kramann Univ. Aachen Germany

November-17

Research Reconnect Consortium

Dirk Duncker (O. Sorop, J. van de Wouw, M. Brandt)

Young@Heart, NHI, Utrecht, The Netherlands

November-18

Fixing a broken heart: make the heart relax again (Winner Scince communication award)

Victor van Hinsbergh (+ Rio Juni)

Visit Dutch Hartstichting Research and Inovation at ErasmusMC

February-20

Research Reconnect Consortium

Dirk Duncker (O. Sorop)

© Reconnext / Netherlands Heart Institute - Website: Consortius Wetenschapscommunicatie