Output

Publications, presentations, dissertations and other public information generated in RECONNECT (2015-2020) and RECONNEXT (2021-2026)

Highlights

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice

Review: prognostic models for cardiovascular disease in patients with chronic kidney disease

Publications

2023

Sen P, Sorop O, Merkus D. Myocardial epigenetic modifications link chronic kidney disease to coronary microvascular disease. Am J Physiol Heart Circ Physiol. 2023 Jan 1;324(1):H175-H176. doi: 10.1152/ajpheart.00677.2022. Epub 2022 Dec 16. PMID: 36525479.
Smit LC, Bots ML, et al., Verhaar MC, Vernooij RWM. One heartbeat away from a prediction model for cardiovascular diseases in patients with chronic kidney disease: a systematic review. Cardiorenal Med. 2023 Feb 20. doi: 10.1159/000529791. Epub ahead of print. PMID: 36806550.
Colombijn JMT, et al., Verhaar MC, Vernooij RWM. Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease: a study protocol of an evidence map. Syst Rev. 2022 Nov 12;11(1):238. doi: 10.1186/s13643-022-02108-x. PMID: 36371302; PMCID: PMC9655868.
de Boer M, Te Lintel Hekkert M, et al., Duncker DJ. DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice. Aging Cell. 2023 Mar;22(3):e13768. doi: 10.1111/acel.13768. Epub 2023 Feb 8. PMID: 36756698; PMCID: PMC10014058.

2022

Nguyen VVT, et al. A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles. J Extracell Vesicles. 2022 Nov;11(11):e12280. doi: 10.1002/jev2.12280. PMID: 36382606; PMCID: PMC9667402.
Duncker DJ, Sorop O, van de Wouw J, et al., Merkus D. Integrated control of coronary blood flow in exercising swine by adenosine, nitric oxide, and K_ATP channels. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1080-H1090. doi: 10.1152/ajpheart.00109.2021. Epub 2022 Oct 7. PMID: 36206049.
van Ommen AMLN, Canto ED, Cramer MJ, Rutten FH, Onland-Moret NC, Ruijter HMD. Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions. BMC Med. 2022 Dec 27;20(1):496. doi: 10.1186/s12916-022-02650-4. PMID: 36575484; PMCID: PMC9795723.
Henkens MTHM, van Ommen AM, et al. den Ruijter HM, Heymans SRB. The HFA-PEFF score identifies ‘early-HFpEF’ phenogroups associated with distinct biomarker profiles. ESC Heart Fail. 2022 Jun;9(3):2032-2036. doi: 10.1002/ehf2.13861. Epub 2022 Mar 17. PMID: 35301820; PMCID: PMC9065816.
van Ham WB, Kessler EL, Oerlemans MIFJ, Handoko ML, Sluijter JPG, van Veen TAB, den Ruijter HM, de Jager SCA. Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models. JACC Basic Transl Sci. 2022 May 25;7(8):844-857. doi: 10.1016/j.jacbts.2021.12.009. PMID: 36061340; PMCID: PMC9436760.

Output from RECONNECT

Title	Authors	Journal	Digital link
α-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes.	Franssen C, Kole J, Musters R, Hamdani N, Paulus WJ.	Circ. Heart Fail.	https://www.ahajournals.org/doi/full/10.1161/circheartfailure.116.003626
What can we learn about treating heart failure from the heart’s response to acute exercise? Focus on the coronary microcirculation.	Heinonen I, Sorop O, de Beer VJ, Duncker DJ, Merkus D.	Appl Physiol	https://journals.physiology.org/doi/full/10.1152/japplphysiol.00053.2015
Waist-hip ratio and Mortality in Heart Failure.	Streng KW, Voors AA, Hillege JL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Lang CC.	EJHF	https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.1244
Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review.	Gohar A, de Kleijn DPV, Hoes AW, Rutten FH, Hilfiker-Kleiner D, Ferdinandy P, Sluijter JPG, den Ruijter HM.	Vascul Pharmacol	https://www.sciencedirect.com/science/article/pii/S1537189117304664?via%3Dihub
Vascular calcification associates with sex-specific vascular miRNA profiles in idiopathic atrial fibrillation patients	Elton AMP Dudink, Barend W Florijn, Bob Weijs , Jacques MGJ Duijs, Justin GLM Luermans, Frederique ECM Peeters, Leon Schurgers, Joachim Wildberger, Uli Schotten, Roel Bijkerk, Harry JGM Crijns and Anton Jan van Zonneveld	microRNA	http://www.eurekaselect.com/167683/article
Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids.	Zhou Z, Lankhuizen IM, van Beusekom HM, Cheng C, Duncker DJ, Merkus D.	Front Pharmacol.	https://www.frontiersin.org/articles/10.3389/fphar.2018.00255/full
Turning The Retrospectroscope On Heart Failure With Preserved Ejection Fraction.	Paulus WJ	J Card Fail.	https://www.onlinejcf.com/article/S1071-9164(16)31157-5/fulltext
Trajectories of Changes in Renal Function in Patients with Acute Heart Failure	Beldhuis IE, Streng KW, van der Meer P, ter Maaten JM, O’Connor CM, Metra M, Dittrich HC, Ponikowski P, Cotter G, Cleland JG, Davison BA, Givertz MM, Teerlink JR, Bloomfield DM, Voors AA, Damman K.	J Card Fail.	https://www.onlinejcf.com/article/S1071-9164(19)30070-3/fulltext
The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis.	Bouthoorn S, Valstar GB, Gohar A, den Ruijter HM, Reitsma HB, Hoes AW, Rutten FH	Diab Vasc Dis Res.	https://journals.sagepub.com/doi/10.1177/1479164118787415
The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis.	Wesseling M, Sakkers TR, de Jager SCA, Pasterkamp G, Goumans MJ.	Vascul Pharmacol	https://www.sciencedirect.com/science/article/pii/S1537189118300065?via%3Dihub
The microcirculation: a key player in obesity-associated cardiovascular disease.	Sorop O, Olver DT, van de Wouw J, Heinonen I, Van Duin RW, Duncker DJ, Merkus D	Cardiovasc Res	https://academic.oup.com/cardiovascres/article/113/9/1035/3803704
TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases.	Pardali E, Sanchez-Duffhues G, Gomez-Puerto MC, Ten Dijke P.	Int J Mol Sci.	https://www.mdpi.com/1422-0067/18/10/2157
Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation.	Oosterhuis NR, Bongartz LG, Verhaar MC, Cheng C, Xu YJ, van Koppen A, Cramer MJ, Goldschmeding R, Gaillard CA, Doevendans PA, Braam B, Joles JA.	Acta Physiol (Oxf).	https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.12829
Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-Derived Endothelial Cells In Vitro	Vincent van Duinen, Wendy Stam, Viola Borgdorff, Arie Reijerkerk, Valeria Orlova, Paul Vulto, Thomas Hankemeier, Anton Jan van Zonneveld,	JOVE	https://www.jove.com/video/59678/standardized-scalable-assay-to-study-perfused-3d-angiogenic-sprouting
Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exercise	S.B. Bender, V.J. de Beer, D.L. Tharp, D.K. Bowles, M.H. Laughlin, D.Merkus, D.J. Duncker	Basic Res Cardiol	https://link.springer.com/article/10.1007%2Fs00395-016-0579-9
Recommended Heart Failure Medications and Adverse Drug Reactions in Women.	Bots SH, den Ruijter HM.	Circulation	https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.118.037585
Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure.	Emmens JE, Ter Maaten JM, Damman K, van Veldhuisen DJ, de Boer RA, Struck J, Bergmann A, Sama IE, Streng KW, Anker SD, Dickstein K, Lang CC, Metra M, Samani NJ, Ng LL, Voors AA.	Circ Heart Fail.	https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118.005544
Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis.	Bouthoorn S, Gohar A, Valstar G, den Ruijter HM, Reitsma JB, Hoes AW, Rutten FH; Queen of Hearts Consortium.	Cardiovasc Diabetol.	https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0690-3
Preeclampsia and coronary plaque erosion: Manifestations of endothelial dysfunction resulting in cardiovascular events in women.	de Jager SCA, Meeuwsen JAL, van Pijpen FM, Zoet GA, Barendrecht AD, Franx A, Pasterkamp G, van Rijn BB, Goumans MJ, den Ruijter HM.	Eur J Pharmacol	https://www.sciencedirect.com/science/article/pii/S0014299917305903?via%3Dihub
Position paper of the European Society of Cardiology-working group of coronary pathophysiology and microcirculation: obesity and heart disease.	Badimon L, Bugiardini R, Cenko E, Cubedo J, Dorobantu M, Duncker DJ, Estruch R, Milicic D, Tousoulis D, Vasiljevic Z, Vilahur G, de Wit C, Koller A.	Eur Heart J	https://academic.oup.com/eurheartj/article/38/25/1951/3813124
Porcine models for studying complications and organ crosstalk in diabetes mellitus.	S Renner, A Blutke, S Clauss, CA Deeg, E Kemter, D Merkus, R Wanke, and E Wolf,	Cell Tissue Res	https://link.springer.com/article/10.1007/s00441-019-03158-9
Phenotypic anti-angiogenic screening assay using iPSC derived endothelium in a perfused microfluidic 3D culture platform	V. van Duinen, W. Stam, E. Mulder, F. Famili, A. Reijerkerk, P. Vulto, T. Hankemeier and A.J. van Zonneveld.	IJMS
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.	Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ.	Circulation	https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.021884
Perturbations in Myocardial Perfusion and Oxygen Balance in Swine With Multiple Risk Factors: A Novel Model of Ischemia and No Obstructive Coronary Artery Disease	van de Wouw J, Sorop O, van Drie RWA, van Duin RWB, Nguyen ITN, Joles JA, Verhaar MC, Merkus D, Duncker DJ.	Basic Res Cardiol	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042191/
Perfused 3D angiogenic sprouting in a high-throughput in vitro platform.	V. van Duinen, D. Zhu, C. Ramakers, A.J. van Zonneveld, P. Vulto and T. Hankemeier	Angiogenesis	https://link.springer.com/article/10.1007/s10456-018-9647-0
Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature.	Wierda E, Dickhoff C, Handoko ML, Oosterom L, Kok WE, de Rover Y, de Mol BAJM, van Heerebeek L, Schroeder-Tanka JM.	ESC Heart Fail.	https://pubmed.ncbi.nlm.nih.gov/32159279/
Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the community	A Gohar, R.F Kievit, G.B Valstar, A.W Hoes, E.E Van Riet, Y van Mourik, L.C Bertens, L.J Boonman-Winter, M.L Bots, H.M den Ruijter and F.H Rutten	Eur J Prev.Card	https://journals.sagepub.com/doi/10.1177/2047487318816774
OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis and elevated fillings pressures in a murine model for heart failure with a preserved ejection fraction.	Van der Pol A, Gil A, Tromp J, Siljé HHW, van Veldhuisen DJ, Voors AA, Hoendermis ES, Grote Beverborg N, Schouten EM, de Boer RA, Bischoff R, van der Meer P.	Cardiovasc Res	https://academic.oup.com/cardiovascres/article/114/14/1871/5056075
Non-cardiac Comorbidities in Heart Failure with Reduced, Mid-range and Preserved Ejection Fraction.	Streng KW, Nauta JF, Hillege JL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Voors AA.	Int J Cardio in press	https://www.internationaljournalofcardiology.com/article/S0167-5273(17)36744-X/fulltext
Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening.	Sorop O, Heinonen I, van Kranenburg M, van de Wouw J, de Beer VJ, Nguyen TN, Octavia Y, van Duin RWB, Stam K, van Geuns RJ, Wielopolski PA, Krestin GP, van den Meiracker AH, Verjans R, van Bilsen M, Danser AHJ, Paulus WJ, Cheng C, Linke WA, Joles JA, Verhaar MC, van der Velden J, Merkus D, Duncker DJ.	Cardiovasc Res	https://academic.oup.com/cardiovascres/article/114/7/954/4844872
Mortality after hospital admission for heart failure: Improvement over time, equally strong in women as in men.	Buddeke J, Valstar GB, van Dis I, Visseren FJ, Rutten FH, den Ruijter HM, Vaartjes I Bots ML, on behalf of the Queen of Hearts and RECONNECT investigators.	BMC Public Health	https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7934-3
Mildly increased renin expression in the absence of kidney injury in the murine trans aortic constriction model	Wesseling M, Mulder E, Brans MAD, Bulthuis M, Pasterkamp G, Verhaar MC, van Goor H, Joles JA, de Jager SCA	submitted to Cardiorenal medicine
Microvascular Paradigm in Heart Failure With Preserved Ejection Fraction: A Quest for Proof of Concept.	Waddingham MT, Paulus WJ.	Circ. Heart. Fail.	https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.117.004179
Lysyl Oxidase-Like 2 Is a Regulator of Angiogenesis Through Modulation of Endothelial-To-Mesenchymal Transition	de Jong OG, van der Waals LM, Kools FRW, Verhaar MC, van Balkom BWM.	J Cell Physiol. 2019 Jul;234(7):10260-10269.	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587725/
Long non-coding RNAs in heart failure: an obvious lnc.	El Azzouzi H, Doevendans PA, Sluijter JP.	Ann Transl Med	http://atm.amegroups.com/article/view/10417/11061
Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction.	Brandt MM, Nguyen ITN, Krebber MM, van de Wouw J, Mokry M, Cramer MJ,Duncker DJ, Verhaar MC, Joles JA, Cheng C.	J Cell Mol Med. 2019	https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14542
Innovations in approaches to remove uraemic toxins.	Masereeuw R, Verhaar MC.	Nat Rev Nephrol. 2020 May 7	https://www.nature.com/articles/s41581-020-0299-0
Inflammation promotes vascular calcification by down-regulating BMPR2 and inducing Endothelial-to-mesenchymal transition.	G. Sánchez-Duffhues, A.G de Vinuesa, M. E. Geerts, M.R. de Vries, S.G. T. Janson, H. van Dam, J. Lindeman, M.J. Goumans, P. ten Dijke.	The Journal of Pathology	https://onlinelibrary.wiley.com/doi/full/10.1002/path.5193
Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1	Pei J, Juni R, Harakalova M, Duncker DJ, Asselbergs FW, Koolwijk P, Hinsbergh VV, Verhaar MC, Mokry M, Cheng C.	Toxins	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723868/
Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.	van den Hoogen P, de Jager SCA, Huibers MMH, et al.	J Cell Mol Med.
Impaired kidney function is associated with intraplaque hemorrhage in patients undergoing carotid endarterectomy.	Wesseling M, van Koeverden ID, van Lammeren GW, van der Laan SW, Haitjema S, de Vries JPM, den Ruijter HM, de Jager SCA, Hoefer I, Blankestijn P, Verhaar M, de Kleijn DPV, de Borst GJ, Pasterkamp G	Artherosclerosis	https://www.atherosclerosis-journal.com/article/S0021-9150%2817%2931307-2/abstract
Immunomodulation in Heart Failure With Preserved Ejection Fraction: Current State and Future Perspectives	Kessler EL, Oerlemans MIFJ, van den Hoogen P, Yap C, Sluijter JPG, de Jager SCA	J Cardiovasc Transl Res	https://link.springer.com/article/10.1007%2Fs12265-020-10026-3
Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction	Tromp J, Westenbrink BD, Ouwerkerk W, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Lang CC, Ng LL, Zannad F, Zwinderman AH, Hillege JL, van der Meer P, Voors AA.	JACC	https://www.sciencedirect.com/science/article/pii/S073510971835407X?via%3Dihub
Hypertension in Dialysis Patients: A Consensus Document by the European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) and the Hypertension and the Kidney Working Group of the European Society of Hypertension (ESH)	Sarafidis PA, Persu A, Agarwal R, Burnier M, de Leeuw P, Ferro CJ, Halimi JM, Heine GH, Jadoul M, Jarraya F, Kanbay M, Mallamaci F, Mark PB, Ortiz A, Parati G, Pontremoli R, Rossignol P, Ruilope L, Van der Niepen P, Vanholder R, Verhaar MC, Wiecek A, Wuerzner G, London GM, Zoccali C.	Nephrol Dial Transplant. 2017 Apr 1;32(4):620-640.	https://academic.oup.com/ndt/article/32/4/620/3069157
Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player	Wesseling M, de Poel JHC, de Jager SCA	ESC Heart failure	https://onlinelibrary.wiley.com/doi/full/10.1002/ehf2.12728
Genome-wide analysis reveals unique chromatin signatures in myocardium of patients with aortic stenosis-induced chronic pressure overload.	J.Y. Pei, M. Harakalova, T.A.Treibel, T. Lumbers, B.J. Boukens, I.R. Efimov, H. El Azzouzi, C.G.M. van Dijk, M.M. Krebber, H. den Ruijter, G. Pasterkamp, D.J. Duncker, E. Nieuwenhuis, R. de Weger, M.M. Huibers, A. Vink, J.H. Moore, J.C. Moon, M.C. Verhaar, M. Mokry, F.W. Asselbergs, C. Cheng.	Submitted
Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts	*G. Sanchez-Duffhues, H. Mikkers, D. de Jong, K. Szuhai, T. J. de Vries, C. Freund, N. Bravenboer, R. J. J. van Es, J. C. Netelenbos, M-J. Goumans, E.M.W. Eekhoff, P. ten Dijke.	Stem Cell Res	https://www.sciencedirect.com/science/article/pii/S1873506119302697
Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure.	Ter Maaten JM, Voors AA, Damman K, van der Meer P, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Navis G, Ng L, Ouwerkerk W, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, de Borst MH.	Int J Cardiol	https://www.internationaljournalofcardiology.com/article/S0167-5273(17)33894-9/abstract
Fibrates in hypertension: where do we stand?	Gremmels H, Joles JA.	J Hypertens.	https://journals.lww.com/
FGF23 impairs peripheral microvascular function in renal failure	Verkaik M, Juni RP, van Loon EPM, van Poelgeest EM, Kwekkeboom RFJ, Gam V, Richards WG, ter Wee PM, Hoenderop JG, Eringa EC, Vervloet, MG	J Physiol Heart Circ Physiol.	https://journals.physiology.org/doi/full/10.1152/ajpheart.00272.2018
Experimental animal models of coronary microvascular dysfunction.	Sorop O, van de Wouw J, Chandler S, Ohanyan V, Tune JD, Chilian WM, Merkus D, Bender SB, Duncker DJ.	Cardiovasc Res	https://academic.oup.com/cardiovascres/article/116/4/756/5700718
Estrogen Contributions to Microvascular Dysfunction Evolving to Heart Failure With Preserved Ejection Fraction.	Sickinghe AA, Korporaal SJA, den Ruijter HM, Kessler EL.	Front Endocrinol (Lausanne).	https://www.frontiersin.org/articles/10.3389/fendo.2019.00442/full
Epoetin Beta and C‐Terminal Fibroblast Growth Factor 23 in Patients With Chronic Heart Failure and Chronic Kidney Disease	Eisenga MF, Emans ME, van der Putten K, Cramer MJ, Diepenbroek A, Velthuis BK, Doevendans PA, Verhaar MC, Joles JA, Bakker SJL, Nolte IM, Braam B, Gaillard CAJM.	J Am Heart Assoc. 2019 Aug 20;8(16):e011130.	https://www.ahajournals.org/doi/full/10.1161/JAHA.118.011130?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry.	Sánchez-Duffhues G, García de Vinuesa A, Ten Dijke P.	Dev Dyn	https://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/dvdy.24589
Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1	Maarten M. Brandt, Christian G. M. van Dijk,Ihsan Chrifi, Heleen M. Kool, Petra E. Bürgisser, Laura Louzao‐Martinez, Jiayi Pei, Robbert J. Rottier, Marianne C.Verhaar, Dirk J. Duncker, Caroline Cheng	Angio	https://link.springer.com/article/10.1007%2Fs10456-018-9625-6
Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction	Rio P. Juni, Rushd Al-Shama, Diederik W.D. Kuster, Jolanda van der Velden, Henrike M. Hamer, Marc G. Vervloet, Etto C. Eringa, Pieter Koolwijk, Victor W.M. van Hinsbergh	Kidney International
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation.	Kolijn D, Pabel S, Tian Y, Lódi M, Herwig M, Carrizzo A, Zhazykbayeva S, Kovács Á, Fülöp GÁ, Falcão-Pires I, Reusch PH, Van Linthout S, Papp Z, van Heerebeek L, Vecchione C, Maier LS, Ciccarelli M, Tschöpe C, Mügge A, Bagi Z, Sossalla S, Hamdani N.	Cardiovascular Research	https://pubmed.ncbi.nlm.nih.gov/32396609/
Empagliflozin for Heart Failure with Preserved Ejection Fraction: targeting endothelial cell-cardiomyocyte interaction.	Juni R, Kuster DWD, Goebel M, Helmes M, van der Velden J, Musters RJ, Koolwijk P, Paulus WJ, van Hinsbergh VWM.	JMCC	https://www.jmmc-online.com/article/S0022-2828(18)30249-9/abstract
Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells	Laween Uthman-Anna Homayr, Rio P Juni, Eva L Spin, Raphaela Kerindongo, Marleen Boomsma, Markus W Hollmann, Benedikt Preckel, Pieter Koolwijk, Victor W M van Hinsbergh, Coert J Zuurbier, Martin Albrecht, Nina C Weber	Cell Physiol Biochem	https://pubmed.ncbi.nlm.nih.gov/31724838/?from_term=juni+r&from_pos=2
Efficient selective screening for heart failure in elderly men and women from the community: A diagnostic individual participant data meta-analysis.	Kievit RF, Gohar A, Hoes AW, Bots ML, van Riet EE, van Mourik Y, Bertens LC, Boonman-de Winter LJ, den Ruijter HM, Rutten FH; Queen of Hearts and RECONNECT consortium.	Eur J Prev Cardiol.	https://journals.sagepub.com/doi/10.1177/2047487317749897
Ebola hemorrhagic shock syndrome-on-a-chip	Abidemi Junaid1,, Huaqi Tang1,, Petra Wuelfroth2, Vincent van Duinen1,3,4, Thomas Hankemeier1, Anton Jan van Zonneveld3,4, Alireza Mashaghi1	iScience	https://www.sciencedirect.com/science/article/pii/S2589004219305103
Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin Dysbalance	Khairoun M, van den Heuvel M, van den Berg BM, Sorop O, de Boer R, van Ditzhuijzen NS, Bajema IM, Baelde HJ, Zandbergen M, Duncker DJ, Rabelink TJ, Reinders ME, van der Giessen WJ, Rotmans JI.	PlosOne	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121555
Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction.	van den Dorpel MMP, Heinonen I, Snelder SM, Vos HJ, Sorop O, van Domburg RT, Merkus D, Duncker DJ, van Dalen BM.	Int J CV Imaging	https://link.springer.com/article/10.1007/s10554-017-1287-8
Distinct Myocardial Targets for Diabetes Therapy in Heart Failure With Preserved or Reduced Ejection Fraction.	Paulus WJ, Dal Canto E	JACC Heart Fail.	https://www.sciencedirect.com/science/article/pii/S2213177917305334?via%3Dihub
Distinct endothelial cell responses in the heart and kidney microvasculature characterize the progression of heart failure with preserved ejection fraction in the obese ZSF1 rat with cardiorenal metabolic syndrome.	van Dijk CG, Oosterhuis NR, Xu YJ, Brandt M, Paulus WJ, van Heerebeek L, Duncker DJ, Verhaar MC, Fontoura D, Lourenço AP, Leite-Moreira AF, Falcão-Pires I, Joles JA, Cheng C.	Circulation HF	https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.115.002760
Dissociation Between Hypertrophy and Fibrosis in the Left Ventricle Early After Experimental Kidney Transplantation	NR Oosterhuis, DA Papazova, M Mokry, MJ Cramer, R Bleys, C Cheng, JA Joles, MC Verhaar	J Hypertens.	https://journals.lww.com/jhypertension/
Dissecting recipient from donor contribution in experimental kidney transplantation: focu on endothelial proliferation and inflammation	DA papazova, MM Krebber, NR Oosterhuis, H Gremmels, AD van Zuilen, JA Joles, MC Verhaar	Dis Models MEch	https://dmm.biologists.org/content/11/7/dmm035030
Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic.	Valstar GB, Bots SH, Groepenhoff F, et al.	BMJ Open
Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.	Aragonez CG, de Beer VJ, Tharp DL, Bowles DK, Laughlin MH, Merkus D, Duncker DJ, Bender SB.	Microcirculation	https://onlinelibrary.wiley.com/doi/abs/10.1111/micc.12539
Diastole Tracks Cardiometabolic Risk.	Paulus WJ, Dal Canto	JACC Heart Fail.	https://heartfailure.onlinejacc.org/content/6/4/326.abstract
Diabetic nephropathy alters the distribution of circulating angiogenic miRNAs over extracellular vesicles, HDL and Ago-2	Barend W. Florijn, Jacques M.G.J. Duijs, Johannes H. Levels, Geesje M. Dallinga-Thie, Yanan Wang, Anita N. Boing, Wendy Stam, Ronald W.A.L. Limpens, Yu Wah Au, Rienk Nieuwland, Ton J. Rabelink, Marlies E.J. Reinders, Anton Jan van Zonneveld and Roel Bijkerk	Diabetes	https://diabetes.diabetesjournals.org/content/68/12/2287
Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells	G. Sánchez-Duffhues, E. Williams, P. Benderitter, V. V. Orlova, M. van Wijhe, A. Garcia de Vinuesa, G. Kerr, J. Caradec, H.C. de Boer, M-J. Goumans, E. M. W. Eekhoff, A. Morales-Piga, J. Bachiller-Corral, P. Koolwijk, A.N. Bullock, J. Hoflack, P. ten Dijke.	JBMR Plus	https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbm4.10230
Coronary microvascular dysfunction in cardiovascular disease: lessons from large animal models	Sorop O, van de Wouw J, Merkus D, Duncker DJ	Bookchapter: Springer Nature	https://link.springer.com/chapter/10.1007/978-3-030-28199-1_2
Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia.	Sorop O, van den Heuvel M, van Ditzhuijzen NS, de Beer VJ, Heinonen I, van Duin RW, Zhou Z, Koopmans SJ, Merkus D, van der Giessen W, Danser AH, Duncker DJ.	Am J Physiol Heart Circ Physiol.	https://journals.physiology.org/doi/full/10.1152/ajpheart.00458.2015
Connecting heart failure with preserved ejection fraction and renal dysfunction – the role of endothelial dysfunction and inflammation	Ter Maaten JM, Damman K, Verhaar MC, Paulus WJ, Duncker DJ, Cheng C, van Heerebeek L, Hillege HL, Lam CS, Navis G, Voors AA.	EUR JHF	https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.497
Comparing biomarker profiles of patients with heart failure: Atrial fibrillation versus Sinus rhythm and reduces versus preserved ejection fraction.	Santema BT, Kloosterman M, van Gelder IC, Mordy I, Lang CC, Lam CSP, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege JL, ter Maaten JM, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Rienstra M, Voors AA.	Eur Heart J	https://academic.oup.com/eurheartj/article/39/43/3867/5077588
CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions	I Chrifi, L. Louzao-Martinez, MM Brand, CGM van Dijk, P E Burgisser, C Zhu, JM Kris, MC Verhaar, DJ Duncker, C Cheng.	Angiogenesis	https://link.springer.com/article/10.1007%2Fs10456-018-9638-1
CMTM3 mediates angiogenesis by regulating cell surface availability of Ve-cadherin in endothelial adherens junctions.	Chrifi I, Louzao-Martinez L, Brandt M, van Dijk C, Burgisser P, Zhu C, Kros J.M, Duncker D.J, Cheng C.	ATVB	https://www.ahajournals.org/doi/10.1161/ATVBAHA.116.308792
Chronic Kidney Disease as a Risk Factor for HFpEF: a Focus on Microcirculatory Factors and Therapeutic Targets.	van de Wouw J, Broekhuizen M, Sorop O, Danser AHJ, Verhaar MC, Joles JA, Duncker DJ, Merkus D	Frontiers in Physiology	https://www.frontiersin.org/articles/10.3389/fphys.2019.01108/full
Chromatin Conformation Links Distal Target Genes to CKD Loci.	MM Brandt, CA Meddens, L Louzao-Martinez, DJ Duncker, MC Verhaar, JA Joles, M Mokry, C Cheng	JASN	https://jasn.asnjournals.org/content/29/2/462.abstract
Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy	L Louzao-Martineza, A Vink, M Harakalova, FW Asselbergs, MC Verhaar, C Cheng.	IJCARD	https://www.internationaljournalofcardiology.com/article/S0167-5273(16)31259-1/fulltext
Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement	Heinonen I, Sorop O, Van Dalen B, Wüst R, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, and Duncker DJ	Sci Rep
CECR1-mediated crosstalk between macrophages and vascular mural cells promotes neovascularization in malignant glioma.	C Zhu, I Chrifi, D Mustafa, M vd Weiden, PJM Leenen, DJ Duncker, JM Kros, C Cheng.	ONCOGENE	https://www.nature.com/articles/onc2017145
Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws.	van Essen GJ, Te Lintel Hekkert M, Sorop O, Heinonen I, van der Velden J, Merkus D, Duncker DJ.	Sci Rep	https://www.nature.com/articles/s41598-017-18775-z
Cardiorenal disease connection during post-menopause: The protective role of estrogen in uremic toxins induced microvascular dysfunction.	Pei J, Harakalova M, den Ruijter H, Pasterkamp G, Duncker DJ, Verhaar MC, Asselbergs FW, Cheng C.	IJCARD	https://www.internationaljournalofcardiology.com/article/S0167-5273(17)31609-1/fulltext
Cardiac Shear Wave Velocity Detection in the Porcine Heart	Vos HJ, van Dalen BM, Heinonen I, Bosch JG, Sorop O, Duncker DJ, van der Steen AF, de Jong N.	Ultrasound Med Biol	https://doi.org/10.1016/j.ultrasmedbio.2016.11.015
Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin	Rio P Juni , Diederik W D Kuster , Max Goebel, Michiel Helmes, René J P Musters, Jolanda van der Velden, Pieter Koolwijk, Walter J Paulus , Victor W M van Hinsbergh	JACC Basic Transl Sci	https://www.sciencedirect.com/science/article/pii/S2452302X1930138X?via%3Dihub
Both Male and Female Obese ZSF1 Rats Develop Cardiac Dysfunction in Obesity-Induced Heart Failure With Preserved Ejection Fraction	Nguyen ITN, Brandt MM, van de Wouw J, van Drie RWA, Wesseling M, Cramer MJ, de Jager SCA, Merkus D, Duncker DJ, Cheng C, Joles JA, Verhaar MC	Plos One	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232399
Bone morphogenetic protein receptors: structure, function and targeting by selective small molecule kinase inhibitors	Gonzalo Sanchez-Duffhues, Eleanor Williams, Marie-José Goumans, Carl-Henrik Heldin, Peter Ten Dijke	Bone	In press
Biomarkers of renal function: towards clinical actionability.	Binnenmars SH, Hijmans RS, Navis G, De Borst MH	Clin Pharmacol	https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/cpt.765
BiomarCaRE Consortium. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium	Magnussen C, Niiranen TJ, Ojeda FM, Gianfagna F, Blankenberg S, Vartiainen E, Sans S, Pasterkamp G, Hughes M, Costanzo S, Donati MB, Jousilahti P, Linneberg A, Palosaari T, de Gaetano G, Bobak M, den Ruijter HM, Jørgensen T, Söderberg S, Kuulasmaa K, Zeller T, Iacoviello L, Salomaa V, Schnabel RB	JACC Heart Fail	https://www.sciencedirect.com/science/article/pii/S2213177918306905?via%3Dihub
An End-User Perspective on Organ-on-a-Chip: Assays and Usability Aspects.	Abidemi Junaid, Alireza Mashaghi, Thomas Hankemeier, Paul Vulto	COBME	https://www.sciencedirect.com/science/article/pii/S246845111730003X
Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement.	Zhou Z, Sorop O, de Beer, VJ, Heinonen I, Cheng C, Dansel AHJ, Duncker DJ, Merkus D	Purinergic Signalling	https://link.springer.com/article/10.1007/s11302-017-9563-6
Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the Literature.	Bots SH, Groepenhoff F, Eikendal ALM, Tannenbaum C, Rochon PA, Regitz-Zagrosek V, Miller VM, Day D, Asselbergs FW, den Ruijter HM.	JACC Heart Fail.	https://www.sciencedirect.com/science/article/pii/S2213177919300307
Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression.	Zhu C, Mustafa D, Zheng PP, van der Weiden M, Sacchetti A, Brandt M, Chrifi I, Tempel D, Leenen PJM, Duncker DJ, Cheng C, Kros JM.	NEURO ONCOL	https://academic.oup.com/neuro-oncology/article/19/5/648/2798200
A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure : Design and rationale of the MONITOR HF multicentre randomised clinical trial.	Brugts JJ, Veenis JF, Radhoe SP, Linssen GCM, van Gent M, Borleffs CJW, van Ramshorst J, van Pol P, Tukkie R, Spee RF, Emans ME, Kok W, van Halm V, Handoko L, Beeres SLMA, Post MC, Boersma E, Lenzen MJ, Manintveld OC, Koffijberg H, van Baal P, Versteegh M, Smilde TD, van Heerebeek L, Rienstra M, Mosterd A, Delnoy PPH, Asselbergs FW, Brunner-La Rocca HP, de Boer RA.	Netherlands Heart Journal	https://pubmed.ncbi.nlm.nih.gov/31776915/
A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients With Severe Limb Ischemia	Gremmels H, Teraa M, de Jager SCA, Pasterkamp G, de Borst GJ, Verhaar MC	Scientific Reports	https://www.nature.com/articles/s41598-019-47217-1

Presentations

2023

BHF Center of Excellence, Oxford BHF CRE Principal Investigators’ emerging theme evening, University of Oxford. Lecture titled: “Coronary Microvascular Dysfunction in Ischaemic Heart Disease: matching in vivo and ex vivo function.”

2022

Frontiers in Cardiovascular Biomedicine Congress held in Budapest. Presentation titled: “Experimental models of coronary microvascular dysfunction: a translational view”.
European Society of Cardiology Congress in Barcelona. Session ‘Asymptomatic Atherosclerotic Coronary Artery Disease’. Presentation titled: “Non-invasive Testing for Endothelial Function: Physiology Predates Anatomy”.
Europhysiology Meeting in Copenhagen. Presentation titled: “Microvascular physiology in health and disease: lessons from large animal models”.
Eurothrombosis & EuroVessels 2022 in Lisbon. Presentation titled: “Role of coronary microvascular dysfunction in cardiovascular disease”.
Netherlands Society for Cardiology (NVvC) in Papendal Sports Center, Arnhem. Presentation titled: “Gender and cardiovascular disease: a translational view”.
12^thCardiovascular Research Days & 28^th Krakow Conference on Endothelium in Krakow. Keynote Lecture titled: “Coronary microvascular endothelial dysfunction in ischaemic heart disease”.

2021

Experimental Biology Meeting 2021 Virtual – Gabor Kaley Memorial Lecture Award: “The Coronary Microvasculature: Small Vessels with Big Responsibilities”.

Output from RECONNECT

Meeting	Date	Title	PI group (+ presenter)
Zurich, Universtats spital	July-05	MicroRNAs in kidney health and disease	Anton Jan Zonneveld
Cardiorenal seminar Aachen	July-05	Tracking the cardiorenal functions of miR-132	Anton Jan Zonneveld
Cardio Vascular Conference (CVC) 2016 Noordwijkerhout, Netherlands	February-16	A human microvascular organ-on-a chip platform to assess circulating factors associated with microvascular destabilization in patients with chronic kidney disease,	Abidemi Junaid, Janine van Gils, Vincent van Duinen, Thomas Hankemeier and Anton Jan van Zonneveld
FCVB, Florence, Italy.	July-16	Vascular Remodeling in Obesity	D. Duncker
FCVB, Florence, Italy.	July-16	Multiple co-morbidities produce left ventricular diastolic dysfunction in a large animal model	Dirk Duncker (O. Sorop)
Paris EURECA-m CME cardiorenal Course program. Faculté de Médecine Lariboisière, Paris, France.	September-16	‘Renal connection to microvascular disease and heart failure with preserved ejection fraction’	M. Verhaar
NHS Papendal	October-16	Poster: The Pathogenic Role of GDF-15 on Microvascular Dysfunction in Cardiorenal Syndrome	Marian Wesseling
Dutch-German Join Vascular Biology Meeting, Leiden, The Netherlands.	November-16	Poster: Lack of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload in mice	S.C.A. de Jager (J.J. de Haan)
Experimental Biology	April-17	Poster presentation Increased NO Sensitivity is Associated with Maintained Coronary Microvascular cGMP-PDE5 Signaling in Exercising Swine with Multiple Co-Morbidities	Dirk Duncker (R. van Drie)
Experimental Biology	April-17	Poster presentation Multiple co-morbidities have detrimental effects on myocardial function and perfusion in a large animal model of diastolic dysfunction	Dirk Duncker (O. Sorop)
Experimental Biology	April-17	Poster presentation Loss of Nitric Oxide Contributes to Perturbations in Myocardial Oxygen Balance in Exercising Swine with Multiple Comorbidities	Dirk Duncker (J. van de Wouw)
ESC Heart Failure, Paris, Fr	April-17	Poster: Lack of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload in mice	S.C.A. de Jager
European Society for Vascular Surgery. Leiden. NL.	May-17	Selected oral communication: Inflammation-induced EndMT facilitates endothelial calcification	Marie-Jose Goumans (G. Sanchez-Duffhues)
LICR-LUMC TGF-β Meeting. Uppsala, SW.	August-17	Selected poster: Inflammation-induced EndMT facilitates BMP-mediated vascular calcification in a BMP type II receptor (BMPR2) dependent manner. *Best poster prize award.	Marie-Jose Goumans (G. Sanchez-Duffhues)
ESC	September-17	Poster presentation Alterations in coronary microvascular NO signaling in exercising swine with multiple comorbidities	Dirk Duncker (O. Sorop)
ESC	September-17	Poster presentation Exacerbated Pulmonary Hypertension and Ventilation Perfusion Mismatch during Exercise in a Swine Model of Chronic Thromboembolic Pulmonary Hypertension	D. Merkus
ESC	September-17	Invited Lecture Pathophysiology of coronary flow and no-reflow	Dirk Duncker
ESC	September-17	Invited Lecture State of the Art: endothelial function and the microcirculation	Dirk Duncker
27^th MGC Symposium. Rotterdam, NL.	September-17	Lecture: Endothelial-to-mesenchymal transition in human disease	Marie-Jose Goumans (G. Sanchez-Duffhues)
Papendal PhD course 2017 – Presentation Prize	October-17	Oral presentation Multiple co-morbidities have detrimental effects on myocardial function and perfusion in a large animal model of diastolic dysfunction	Dirk Duncker (J. van de Wouw)
CVON PHAEDRA Fall Meeting. The Hague. NL.	October-17	Invited speaker: Inflammation and endothelial-to-mesenchymal transition	Marie-Jose Goumans (G. Sanchez-Duffhues)
NHS Papendal	October-17	Poster: Endothelial-to-mesenchymal transition in cardiorenal syndrome	Marian Wesseling
8^th Rembrandt Symposium. Noordwijkerhout. NL.	November-17	8^th Rembrandt Symposium. Noordwijkerhout. NL.	Marie-Jose Goumans (G. Sanchez-Duffhues)
Frontiers in Cardiovascular Biology. Viena	April-18	Selected poster: Inflammation-induced EndMT facilitates BMP-mediated vascular calcification in a BMP type II receptor (BMPR2) dependent manner. *Best poster prize award.	Marie-Jose Goumans (G. Sanchez-Duffhues)
Frontiers in Cardiovascular Biology, Viena	April-18	Poster: The absence of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload	S.C.A. de Jager (M. Wesseling)
2^ndTranslational Cardiovascular Research Meeting, Netherlands Heart Institute, Utrecht, The Netherlands.	June-18	Poster presentation Multiple Comorbidities Lead to Impaired Myocardial Oxygen Balance and Ischemia in Exercising Swine	Daphne Merkus (J. van de Wouw)
2^ndTranslational Cardiovascular Research Meeting, Netherlands Heart Institute, Utrecht, The Netherlands.	June-18	Selected poster presentation, Cardiac microvascular endothelial cell regulation on cardiomyocyte contraction and relaxation: the role of inflammatory activation and empagliflozin treatment (moderated poster presentation)	Victor van Hinsbergh
International Vascular Biology Meeting, Helsinki, Finland.	June-18	Poster presentation, Cardiac microvascular endothelial cells improve cardiomyocyte function: the role of nitric oxide and empagliflozin treatment	Victor van Hinsbergh
FCVB	July-18	Poster Presentation Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities	Dirk Duncker (O. Sorop)
FCVB	July-18	Poster Presentation Maintained cGMP-PDE5 signaling in coronary microvascular of swine with multiple co-morbidities	Dirk Duncker (R. van Drie)
FCVB	July-18	Poster Presentation Loss of Nitric Oxide Contributes to Perturbations in Myocardial Oxygen Balance in Exercising Swine with Multiple Comorbidities	Daphne Merkus (J. van de Wouw)
FCVB	July-18	Invited Lecture Exercise and the coronary circulation in health and disease	Dirk Duncker
International Society for Heart Research European Section, Amsterdam, The Netherlands.	July-18	Oral and poster presentation, Empagliflozin for heart failure with preserved ejection fraction: targeting cardiac endothelial cell-cardiomyocyte interaction	Victor van Hinsbergh
ISHR (Poster price)	July-18	Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple Comorbidities	Daphne Merkus (J. van de Wouw)
ESC	August-18	Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple Comorbidities	Daphne Merkus (J. van de Wouw)
12th BMP International Conference. Tokyo, JP.	October-18	Selected oral presentation: Identification of Novel Macrocyclic ALK2 inhibitors for Fibrodysplasia ossificans progressiva using patient-derived endothelial colony forming cells	Marie-Jose Goumans (G. Sanchez-Duffhues)
Dutch-German Join Vascular Biology Meeting, Amsterdam, The Netherlands.	November-18	Poster presentation, The role of pro-inflammatory stimulation and Empagliflozin treatment	Victor van Hinsbergh
AHA	November-18	Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple Comorbidities	Daphne Merkus (J. van de Wouw)
DEBS	November-18	Poster presentation, Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple Comorbidities	Daphne Merkus (J. van de Wouw)
AHA	November-18	Poster presentation, Alterations in ROS-NO signaling in Exercising Swine with Multiple Comorbidities	Daphne Merkus (O. Sorop)
Dutch German Vascular Biology meeting. Amsterdam, NL.	November-18	Selected poster: Identification of Novel Macrocyclic ALK2 inhibitors for Fibrodysplasia ossificans progressiva using patient-derived endothelial colony forming cells	Marie-Jose Goumans (G. Sanchez-Duffhues)
DZHK-Munich Heart Alliance	February-19	Invited oral presentation: Cardiac changes in swine models of left and right heart disease	Daphne Merkus
Dutch German Molecular Cardiology meeting. Göttingen, GE.	March-19	Selected poster: Inflammation-induced EndMT facilitates BMP-mediated vascular calcification in a BMP type II receptor (BMPR2) dependent manner. *Best poster prize award.	Marie-Jose Goumans (G. Sanchez-Duffhues)
Dutch-German Cardiovascular Joint Meeting, Gottingen, Germany	March-19	Cardiac microvascular endothelial cells improve cardiomyocyte contractilefunction: The role of pro-inflammatory stimulation and Empagliflozin treatment (poster presentation)	Victor van Hinsbergh (+ Rio Juni)
Experimental Biology	April-19	Poster presentation, Alterations in ROS-NO signaling in Exercising Swine with Multiple Comorbidities	Dirk Duncker (O. Sorop)
Experimental Biology	April-19	Poster presentation Alterations in Myocardial Oxygen Balance, Anaerobic Metabolism and Diastolic Dysfunction in Exercising Swine with Multiple Comorbidities	Daphne Merkus (J. van de Wouw)
Experimental Biology	April-19	Poster presentation Limited synergy between major risk factors obesity and hypertension in development of HFpEF	C. Cheng and Daphne Merkus (M. Brandt)
Experimental Biology	April-19	Poster presentation Pulmonary vascular disease in swine model with multiple comorbidities	Daphne Merkus (J. Steenhorst)
UMCU Medical Physiology group, invited lecture	April-19	Invited speaker: Growth Differentiation Factor 15 in cardiovascular disease: innocent bystander or major culprit?	S.C.A. de Jager
European Society of Microcirculation and European Vascular Biology Organization joined Meeting, Maastricht, The Netherlands (Best abstract)	April-19	Cardiac microvascular endothelial cells improve cardiomyocyte contractilefunction: The role of pro-inflammatory stimulation and Empagliflozin treatment (poster presentation, best abstract)	Victor van Hinsbergh (+ Rio Juni)
ECSM 2019	June-19	Invited oral presentation: Myocardial perfusion and oxygenation durig exercise in health and disease	Daphne Merkus
International Society of Heart Research World Congress, Beijing, China	June-19	Empagliflozin Ameliorates Uremia-Induced Oxidative Damage in Cardiac Microvascular Endothelial Cells (poster presentation, HFpEF session chairman)	Victor van Hinsbergh (+ Rio Juni)
Society for Heart and Vascular Metabolism Meeting, Amsterdam, The Netherlands	June-19	Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function is Impaired by Inflammation and Restored by Empagliflozin (poster presentation)	Victor van Hinsbergh (+ Rio Juni)
Physiology 2019	July-19	Invited oral presentation: Coronary microcirculation in left and right heart failure	Daphne Merkus
Amsterdam Cardiovascular Science Symposium, Amsterdam, The Netherlands	July-19	Cardiac microvascular endothelial cells improve cardiomyocyte contractilefunction: The role of pro-inflammatory stimulation and Empagliflozin treatment (poster presentation)	Victor van Hinsbergh (+ Rio Juni)
ESC-Best of Cardiovascular Research	September-19	Invited oral presentation in symposium ‘Best of Cardiovascular Research’: Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening.	DJ Duncker
German Vascular Biology Meeting, Heidelberg, Germany	October-19	Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function is Impaired by Inflammation and Restored by Empagliflozin (oral presentation)	Victor van Hinsbergh (+ Rio Juni)
Rembrandt Meeting, Noordwijkerhout, The Netherlands	November-19	Empagliflozin Ameliorates Uremia-Induced Oxidative Damage in Cardiac Microvascular Endothelial Cells (oral/poster presentation)	Victor van Hinsbergh (+ Rio Juni)
MDR Annual Meeting 2019	December-19	A multiorgan-on-a-chip diabetic nephropathy model for medium-high throughput screening of candidate therapies for kidney regeneration	MC Verhaar (V. Nguyen)
UMC Utrecht, Research Colloquium	February-20	Invited speaker: GDF15 and endoMT: Mediating vascular dysfunction in heart failure?	Marian Wesseling
Dutch Physiology Day, Utrecht, The Netherlands	February-20	Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Uremic Serum and Restored by Empagliflozin (oral presentation)	Victor van Hinsbergh (+ Rio Juni)
Human Disease Model Technology annual meeting, Rotterdam, The Netherlands	February-20	Cardiac Microvascular Endothelial Enhancement Of Cardiomyocyte Function Is Impaired By Uremic Serum And Restored By Empagliflozin (oral presentation)	Victor van Hinsbergh (+ Rio Juni)
Dutch German Meeting of Molecular cardiology (did not take place)	March-20	large animal models of Cardiorenal syndrome	Daphne Merkus
Experimental Biology 2020-Online Congress	April-20	Gabor Kaley Memorial Lecture Award’ winner and symposium organizer The Coronary Microvasculature: Small Vessels with Big Responsibilities	Dirk Duncker
Experimental Biology 2020-Online Congress	April-20	Oral presentation Diabetic metabolic dysregulation and chronic kidney disease induce specific perturbations in coronary microvascular function in swine	Dirk Duncker (O. Sorop)
Experimental Biology 2020-Online Congress	April-20	Oral presentation Impaired Oxygenation of the Right Ventricle during Development of Pulmonary Hypertension in Swine is not due to Loss of Nitric Oxide	Daphne Merkus
Amsterdam UMC-VU Biomedical Sciences Lecture	April-20	Oral presentation Myocardial perfusion in health and disease	Dirk Duncker (O. Sorop)
FCVB 2020 -cancelled	April-20	Accepted poster presentation Pulmonary vascular disease in a swine model of chronic kidney disease and metabolic derangement	Daphne Merkus (J. Steenhorst)
FCVB 2020 -cancelled	April-20	Accepted poster presentation Increased oxidative stress alters coronary microvascular tone in exercising swine with multiple comorbidities	Dirk Duncker (O. Sorop)
FCVB 2020 -cancelled	April-20	Accepted poster presentation Myocardial perfusion abnormalities and anaerobic metabolism in exercising swine with multiple comorbidities due to loss of nitric oxide	Dirk Duncker (J. van de Wouw)
American Diabetes Association 80th scientific session (On-line)	June-20	Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Uremic Serum and Restored by Empagliflozin (poster presentation)	Victor van Hinsbergh (+ Rio Juni, Etto Eringa)
ESC 2020	September-20	Accepted poster presentation Coronary microvascular dysfunction results in impaired coronary flow reserve and altered oxygen balance in a swine model of INOCA with multiple risk factors	Dirk Duncker (O. Sorop)
Frontiers in Cardiovascular Biology, Florence, It	july-2016	Poster: Lack of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload in mice	S.C.A. de Jager
ISHR	July-2018	Poster presentation, Alcohol Consumption and Risk of New Onset Heart Failure in Patients with Type 2 Diabetes Mellitus	G Navis (SH Binnenmars)
RECONNECT summerschool	June 2019	CDK-HFpEF Interactions: a Platform for in vitro Simulation	MC Verhaar (B.W.M. van Balkom)
ESC summerschool	june-2017	Poster: Endothelial-to-mesenchymal transition in cardiorenal syndrome	Marian Wesseling
UMCG Groningen, NL	june-2018	Invited Lecture: Growth Differentiation Factor 15 in cardiovascular disease: innocent bystander or major culprit?	S.C.A. de Jager
3th Translational Cardiovascular meeting. Utrecht, NL	june-2019	Poster: The absence of Growth Differentiation Factor 15 aggravates adverse cardiac remodeling upon pressure-overload via BMP signalling	S.C.A. de Jager (M. Wesseling)
YOUNG TALENT
poster presentatie EB2019, Orlando	2019	Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction	M. Brandt
MDR Annual Meeting	dec-19	A multiorgan-on-a-chip diabetic nephropathy model for medium-high throughput screening of candidate therapies for kidney regeneration	V. Nguyen
RECONNECT summerschool	June-2019	CDK-HFpEF Interactions: a Platform for in vitro Simulation	B. van Balkom
RECONNECT Meeting	June-2019	Determining the role of uremic toxins on cardiac electrophysiology and arrhythmias during chronic kidney disease – An Update	W. Van Ham
RECONNECT Meeting Summerschool	1-9-2019	Determining the role of uremic toxins on cardiac electrophysiology and arrhythmias during chronic kidney disease	W. Van Ham
Dutch German Joint Meeting of Molecular Cardiology	March-2020	Determining the role of uremic toxins on cardiac electrophysiology and arrhythmias during chronic kidney disease	W. Van Ham
RECONNECT summerschool	sep-19	Single-cell RNA sequencing approach to map perivascular pericytes transition to myofibroblasts during the development of HFpEF in ZSF1 rat heart	Ch. Van Dijk
Gordon Research Conference in Epigenetic Regulation of Cardiovascular Disease, Hong Kong	May-2019	The novel lncRNA Titin antisense-1 shows promise as a circulating biomarker and key mediator of heart failure with preserved ejection fraction pathophysiology in females	E.L. Robinson
British Society for Cardiovascular Research Heart Failure meeting Cambridge, UK.	sep-19	A NOVEL REGULATORY LONG NON-CODING RNA EXHIBITS SEX DIFFERENCES IN HEART FAILURE WITH PRESERVED EJECTION FRACTION	E.L. Robinson
International Society of Heart Failure Research (ISHR)	2019	A NOVEL REGULATORY LONG NON-CODING RNA EXHIBITS SEX DIFFERENCES IN HEART FAILURE WITH PRESERVED EJECTION FRACTION	E.L. Robinson
HFA Winter meetng Invited talk Les Diablerets, Switzerland.	January-2019	TTN-an.sense-1 as a sex-specific biomarker and novel molecular target for therapy in HFpEF	E.L. Robinson
ISHR Cardiovascular webinar series	April 2020	TTN-an.sense-1 as a sex-specific biomarker and novel molecular target for therapy in HFpEF	E.L. Robinson
ISHR-ES/SERVIER meeting	February-2018	Energy insufficiency-mediated ADP elevations as cause of diastolic dysfunction	V. Sequeira
RECONNECT summerschool	sep-19	Energy insufficiency-mediated ADP elevations as cause of diastolic dysfunction	V. Sequeira
34th ISHR-European Section Meeting	July-2017	Energy insufficiency-mediated ADP elevations as cause of diastolic dysfunction	V. Sequeira
10th Asia Pacific Heart Rhythm Society Meeting	sep-17	Enhancing mitochondrial bioenergetics with SS31 recovers ventricular conduction abnormalities caused by energy-deprivation in a cTnT HCM mouse	V. Sequeira
Annual meeting of the Working Groups on Myocardial Function and Cellular Biology of the Heart of the ESC	May-2017	Energy insufficiency in human hypertrophic cardiomyopathy caused by depressed energy-buffering systems	V. Sequeira
Amsterdam Cardiovascular Sciences Symposium	apr-17	Energy insufficiency-mediated ADP elevations as cause of diastolic heart failure	V. Sequeira

Dissertations

Output from RECONNECT

Name	Title	Date
Koen Streng	Non-cardiac comorbidities in heart failure with preserved ejection fraction	12-jun-19
Marian Wesseling	Connecting vascular inflammation and endothelial dysfunction in the cardiorenal axis	20-okt-20
Gideon Valstar	Left Ventricular Diastolic Dysfunction towards a HELPFul role for biomarkers	17-nov-20
Jens van de Wouw	Distinctive Alterations in Microvascular Function due to Multiple Common Morbidities	14-dec-20
Isabel Nguyen	Comorbidities in the Cardiorenal Syndrome	2021
Chris van Dijk	nog niet bekend	2021
Abidemi Junaid	Microengineered Human Blood Vessels For Next Generation Drug Discovery

Public information

Output from RECONNECT

Prognose na ziekenhuisopname voor hartfalen. Buddeke J, Valstar GB, van Dis I, Visseren FL, Bots ML, den Ruijter HM, Vaartjes I. Hart- en vaatziekten in Nederland 2017: Cijfers over leefstijl, risicofactoren, ziekte en sterfte. Den Haag: Hartstichting, 2017:55-64. (PDF)
Kerncijfers over hart- en vaatziekten. De Boer AR, van Dis I, Vaartjes I, Bots ML. Hart- en vaatziekten in Nederland 2019: 25 jaar cijfers over incidentie, prevalentie, ziekte en sterfte. Den Haag: Hartstichting, 2019; 51-78. (PDF)

Non-scientific presentations

Meeting	Date	Title	PI group (+ presenter)
Visit Patient association CKD and Heart Failure at ErasmusMC	December-16	Research Reconnect Consortium	Dirk Duncker (O. Sorop, M. Brandt)
Visit prof. G. Kararigas Univ Charite Berlin	June-17	Research Reconnect Consortium	Dirk Duncker (O. Sorop, J. van de Wouw)
Visit prof. J. Daemen Amsterdam UMC	November-17	Three common comorbidities and their effect on the (coronary) microcirculation	Dirk Duncker (J. van de Wouw)
Visit prof. R. Kramann Univ. Aachen Germany	November-17	Research Reconnect Consortium	Dirk Duncker (O. Sorop, J. van de Wouw, M. Brandt)
Young@Heart, NHI, Utrecht, The Netherlands	November-18	Fixing a broken heart: make the heart relax again (Winner Scince communication award)	Victor van Hinsbergh (+ Rio Juni)
Visit Dutch Hartstichting Research and Inovation at ErasmusMC	February-20	Research Reconnect Consortium	Dirk Duncker (O. Sorop)